Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

Abstract

Ovarian cancer ranks seventh in the most common malignant tumors among female disease, which seriously threatens female reproductive health. It is characterized by hidden pathogenesis, missed diagnosis, high reoccurrence rate, and poor prognosis. In clinic, the first-line treatment prioritized debulking surgery with paclitaxel-based chemotherapy. The harsh truth is that female patients are prone to relapse due to the dissemination of tumor cells and drug resistance. In these circumstances, the development of new therapy strategies combined with traditional approaches is conductive to improving the quality of treatment. Among numerous drug resources, botanical compounds have unique advantages due to their potentials in multitarget functions, long application history, and wide availability. Previous studies have revealed the therapeutic effects of bioactive plant components in ovarian cancer. These natural ingredients act as part of the initial treatment or an auxiliary option for maintenance therapy, further reducing the tumor and metastatic burden. In this review, we summarized the functions and mechanisms of natural botanical components applied in human ovarian cancer. We focused on the molecular mechanisms of cell apoptosis, autophagy, RNA and DNA lesion, ROS damage, and the multiple-drug resistance. We aim to provide a theoretical reference for in-depth drug research so as to manage ovarian cancer better in clinic.

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

“…Along with safety concerns, it is also difficult to meet clinical needs [ 19 – 21 ]. Pilot studies have shown that TCM, including MAP 30 and Paclitaxel, has been extensively applied to treat ovarian cancer effectively [ 8 – 10 , 14 ]. However, despite extensive clinical research, the clinical efficacy of TCM is still not well understood.…”

“…Evidence-Based Complementary and Alternative Medicine [8][9][10]14]. However, despite extensive clinical research, the clinical efficacy of TCM is still not well understood.…”

“…Previously, traditional Chinese medicine (TCM) has been extensively applied as a promising adjunctive drug in the fight against ovarian cancer [ 7 , 8 ]. For instance, bitter lemon seeds-derived MAP 30 [ 9 ] and yew-derived Paclitaxel [ 10 ] have recently achieved safe and curative effects against ovarian cancers. The scant research literature and the shortcomings associated with clinical trial design and quality control limit the application of TCM as a viable regimen against ovarian cancer.…”

Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

“…Natural compounds with effective anti-cancer activities are generally active substances extracted from plants and can be classified as glycosides, flavonoids, terpenoids, alkaloids and saponins [ 26 , 27 ]. Most of these compounds exhibit selective inhibition to cancer cells, but show mild toxicity to normal cells, and tolerable side effects to patients.…”

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

“…Cancer is a significant global public health issue and has the second highest mortality rate in the United States, accounting for about 610.000 deaths in 2022 . The use of natural plant elements as an alternative to chemotherapy or chemopreventive drugs is an effective strategy in the fight against cancer, especially with the possibility of targeting cancerous cells without healthy cells …”