2024
DOI: 10.3390/v16040542
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Mechanisms and Cardiorenal Complications of Chronic Anemia in People with HIV

Kingsley Kamvuma,
Benson M. Hamooya,
Sody Munsaka
et al.

Abstract: Chronic anemia is more prevalent in people living with HIV (PLWH) compared to the general population. The mechanisms that drive chronic anemia in HIV are multifaceted and include functional impairment of hematopoietic stem cells, dysregulation of erythropoietin production, and persistent immune activation. Chronic inflammation from HIV infection adversely affects erythropoiesis, erythrocyte lifespan, and erythropoietin response, leading to a heightened risk of co-infections such as tuberculosis, persistent sev… Show more

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Cited by 5 publications
(1 citation statement)
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“…The pathogenesis of anaemia in virally suppressed PLWH remains unclear. However, sub-optimal chronic inflammation, even in the absence of active viral replication, contributes to disrupted erythropoiesis [7], [8]. Inflammatory cytokines interfere with iron metabolism, impairing red blood cell production [9].…”
Section: Introductionmentioning
confidence: 99%
“…The pathogenesis of anaemia in virally suppressed PLWH remains unclear. However, sub-optimal chronic inflammation, even in the absence of active viral replication, contributes to disrupted erythropoiesis [7], [8]. Inflammatory cytokines interfere with iron metabolism, impairing red blood cell production [9].…”
Section: Introductionmentioning
confidence: 99%