Mechanisms and clinical application of Xuebijing injection, a traditional Chinese herbal medicine–a systematic review

Chen, Mengchi; Shu, Wenbo; Zhang, Jingfeng; Huang, Hongyuan; Liu, Jianghua

doi:10.1007/s13596-023-00702-5

Cited by 1 publication

(1 citation statement)

References 68 publications

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“…A systematic review of 90 studies conducted over the last 20 years on the mechanisms of action of XBJ in clinical applications suggests that XBJ can reduce IL-2, IL-4, TNF-α and oxidative stress by modulating various signalling pathways, such as PI3K-AKT, NF-κB and MAPK. Additionally, it plays a role in cell protection, stabilizing haemodynamics, regulating metabolic processes and enhancing immune function [ 78 ].…”

Section: Chinese Herbal Medicines As Potential Therapeutic Agents For...mentioning

confidence: 99%

Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines

Yu,

Zhou,

Kapini

et al. 2024

Medicines

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Cytokine storm (CS) is the main driver of SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) in severe coronavirus disease-19 (COVID-19). The pathological mechanisms of CS are quite complex and involve multiple critical molecular targets that turn self-limited and mild COVID-19 into a severe and life-threatening concern. At present, vaccines are strongly recommended as safe and effective treatments for preventing serious illness or death from COVID-19. However, effective treatment options are still lacking for people who are at the most risk or hospitalized with severe disease. Chinese herbal medicines have been shown to improve the clinical outcomes of mild to severe COVID-19 as an adjunct therapy, particular preventing the development of mild to severe ARDS. This review illustrates in detail the pathogenesis of CS-involved ARDS and its associated key molecular targets, cytokines and signalling pathways. The therapeutic targets were identified particularly in relation to the turning points of the development of COVID-19, from mild symptoms to severe ARDS. Preclinical and clinical studies were reviewed for the effects of Chinese herbal medicines together with conventional therapies in reducing ARDS symptoms and addressing critical therapeutic targets associated with CS. Multiple herbal formulations, herbal extracts and single bioactive phytochemicals with or without conventional therapies demonstrated strong anti-CS effects through multiple mechanisms. However, evidence from larger, well-designed clinical trials is lacking and their detailed mechanisms of action are yet to be well elucidated. More research is warranted to further evaluate the therapeutic value of Chinese herbal medicine for CS in COVID-19-induced ARDS.

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Section: Chinese Herbal Medicines As Potential Therapeutic Agents For...mentioning

confidence: 99%

Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines

Yu,

Zhou,

Kapini

et al. 2024

Medicines

View full text Add to dashboard Cite

show abstract

Mechanisms and clinical application of Xuebijing injection, a traditional Chinese herbal medicine–a systematic review

Cited by 1 publication

References 68 publications

Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines

Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines

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