Mechanisms and mediators of nasal symptoms in non‐allergic rhinitis

Salib, Rami J.; Harries, Philip G.; Nair, Sona; Howarth, PH

doi:10.1111/j.1365-2222.2007.02926.x

Cited by 55 publications

(50 citation statements)

References 107 publications

(128 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We are confident of the validity of our finding of the allergenic effects of grass pollen because of the detailed taxonomic identification of the overall pollen count, the measurement of pollen at two sites to assess their regional variation, and the ability to include data for several important confounders in the analyses. These included the daily air temperature and humidity, particulate air pollution, and respiratory viral illness, all of which can be seasonally associated with rhinitis (Cashel et al, 2004;Salib et al, 2008). Although the pattern of pollen distribution recorded by our two monitors was generally similar, with fixed monitors, sampling is inevitably biased towards widely dispersed, wind pollinated species such as Poaceae.…”

Section: Discussionmentioning

confidence: 99%

Pollen Loads and Allergic Rhinitis in Darwin, Australia: A Potential Health Outcome of the Grass-Fire Cycle

2009

View full text Add to dashboard Cite

Although the prevalence of asthma and allergic rhinitis has been increasing in tropical regions, little is known about the allergenicity of pollens from tropical plant families or the importance of ongoing environmental changes. We investigated associations between daily average pollen counts of several tropical plant families and sales of medications for the treatment of allergic rhinitis in Darwin, Australia-a tropical setting in which grass abundance has increased due to increased fire frequencies and the introduction of African pasture grasses. Daily pollen counts with detailed identification of plant species were undertaken in conjunction with a weekly survey of flowering plant species from April 2004 to November 2005. Five pharmacies provided daily sales data of selected medications commonly used to treat allergic rhinitis. We used generalized linear modeling to examine outcomes.All analyses accounted for the potential confounding effects of time trends, holidays, respiratory viral illnesses, meteorological conditions, and air pollution. The peak total pollen count was 94 grains/m 3 . Despite the low levels of Poaceae (grass) pollen (maximum daily count, 24 grains/m 3 ), there was a clear association with daily sales of anti-allergic medications greatest at a lag of 1 day. Sales increased by 5% with an interquartile range rise (3 grain/ m 3 ) in Poaceae pollen (5.07%, 95%CI 1.04%, 9.25%). No associations were observed with pollen from other plant families. Although further testing is required, we suggest that an overlooked aspect of the ''grass-fire cycle'' that is degrading many tropical landscapes, could be an increase in the prevalence of allergic rhinitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Pollen Loads and Allergic Rhinitis in Darwin, Australia: A Potential Health Outcome of the Grass-Fire Cycle

2009

View full text Add to dashboard Cite

show abstract

“…On the other hand, the nervous system plays an important role in the local regulation of allergic inflammation [11]. Substance p is a neuropeptide released from the sensory nerves of the upper respiratory tract and stimulates ‘neurogenic inflammation’ by inducing glandular secretion, plasma leakage, vasodilatation, cholinergic activation, and inflammatory cell infiltration with its receptors on sensory neurons, mucosal glands, epithelial and inflammatory cells [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Substance p is a neuropeptide released from the sensory nerves of the upper respiratory tract and stimulates ‘neurogenic inflammation’ by inducing glandular secretion, plasma leakage, vasodilatation, cholinergic activation, and inflammatory cell infiltration with its receptors on sensory neurons, mucosal glands, epithelial and inflammatory cells [11,12,13]. As allergens increase the amount of neuropeptide production by histamine receptors on sensory nerves [14], neurotransmitters also induce histamine release by mast cell degranulation [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

Kavut

Kalpaklıoğlu

Atasoy

2012

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: A neuroallergic interaction was reported in the pathogenesis of allergic rhinitis (AR), but the pathophysiology of nonallergic rhinitis (NAR) is poorly understood. We aimed to explore the contribution of neuroallergic mechanisms to the pathogenesis of NAR. Methods: Subjects were divided into three groups – NAR patients (n = 25), AR patients (n = 16) and the control group (n = 10) – and were assessed using the nasal provocation test (NPT) with house dust mite. Total symptom scores, nasal inspiratory peak flow and nasal lavage were performed before and after NPT. Nasal brushing and scraping was done after NPT. Results: NPT was positive in NAR (52%) and AR (100%) patients and negative in all controls. After NPT, total symptom scores increased in both rhinitis groups. Post-NPT values of nasal inspiratory peak flow decreased only in AR patients. NAR patients showed a similar inflammatory cell profile in the nasal smears to AR patients which was different in controls. There were more tryptase- and immunoglobulin E (IgE)-positive cells in the nasal mucosa of AR patients, and more substance-p-positive cells were observed in NAR patients compared with controls. However, IgE- and tryptase-positive cells in NAR patients and substance-p-positive cells in AR patients were detectable in nasal mucosa, but rarely in the controls. Comparing the values before and after NPT, tryptase significantly increased in the nasal lavages of AR and NAR patients, while house dust mite-specific IgE did not change. Conclusions: We showed the existence of a common pathophysiological mechanism with different contributions in AR and NAR. We conclude that the difference in dominance of neuroallergic ways may determine the major phenotype of rhinitis.

show abstract

“…These various influences include infection, hormonal fluctuations, pharmacological agents, and autonomic dysfunction. (Salib et al 2008) Vasomotor rhinitis (VMR) is the most common form of chronic NAR with the clinical presentations including nasal obstruction, postnasal drip, itching, clear rhinorrhea, epiphora, crocodile tears and Sluder syndrome. It has been thought to result from an imbalance in the autonomic input to the nasal mucosa with increased parasympathetic stimulation without adequate sympathetic balance.…”

mentioning

confidence: 99%

Endoscopic Vidian Neurectomy: The Anatomy Consideration and Preoperative Images Analysis

Su¹,

Liu²,

Wang³

2012

Computed Tomography - Clinical Applications

View full text Add to dashboard Cite

IntroductionAlthough surgery is not a primary treatment for manaing rhinitis, it can have some adjuvant benefit in patients with significant nasal congestion or poor pharmacologic response. It is usually performed by surgical approaches to the inferior turbinate, and the more aggressive procedures such as the vidian neurectomy have not been widely applied. Traditional approaches to the vidian canal necessitate larger incisions, including transseptal, transpalatal and transantral methods. These approaches are often not reliable and at the risk of injury to the abutting neurovascular structures. Pioneers in endoscopic surgery are exploring alternatives to these traditional techniques in an attempt to minimize morbidity and the lack of irrelevant incisions. The main difficulties encountered during endoscopic approach are anatomic variations such as canal wall dehiscence, intra-sphenoid septa, pneumatization degree of pterygoid process and the relationship between vidian canal and middle turbinate. Those variations will have effect in determining the surgical success rate and the related complications. Therefore, a powerful tool, in the purpose of identifying the canal location and its surrounding anatomy, is very important to guide the surgeon in preoperative assessment and intraoperative approach. Computed tomography (CT) scanning is superior for the evaluation of the bony confines of the sinonasal tract and skull base. The most minimal recesses of the sinonasal region are easily assessed and it is possible to evaluate the position and configuration of the vidian canal. That valuable information provided by imaging studies enhances the surgical feasibility and offers an alternative for treating the rhinitis. This chapter describes the use of CT images in this capacity. Growing surgical experience and evolving technology will help to advance the feasibility of endoscopic vidian neurectomy and elucidate their indications by using preoperative images.

show abstract

Mechanisms and mediators of nasal symptoms in non‐allergic rhinitis

Cited by 55 publications

References 107 publications

Pollen Loads and Allergic Rhinitis in Darwin, Australia: A Potential Health Outcome of the Grass-Fire Cycle

Pollen Loads and Allergic Rhinitis in Darwin, Australia: A Potential Health Outcome of the Grass-Fire Cycle

Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

Endoscopic Vidian Neurectomy: The Anatomy Consideration and Preoperative Images Analysis

Contact Info

Product

Resources

About