2023
DOI: 10.1007/s12020-023-03642-x
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Mechanisms and risk factors of metabolic syndrome in children and adolescents

Valentina Codazzi,
Giulio Frontino,
Luca Galimberti
et al.

Abstract: Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity, elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The diagnostic criteria for MetS in adults are well-established, but there is currently no consensus on the definition in children and adolescents. The etiology of MetS is believed to involve a complex interplay between genetic predisposition and environmental factors. While genetic predisposition explains only a small part of MetS pathogenesis,… Show more

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Cited by 14 publications
(4 citation statements)
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“…Recent local studies have highlighted poor dietary practices and patterns among Malaysian children and adolescents, which have been linked to a poor quality of life [51][52][53] . Moreover, unhealthy dietary habits established at a young age are associated with an increased risk of cardiometabolic diseases and poor quality of life [52][53][54][55][56] . These age-, sex-and ethnic-specific variations in our SEACO-CH20 study highlight the importance of tailoring nutritional interventions to address the unique dietary preferences and cultural contexts of different ethnic communities.…”
Section: Discussionmentioning
confidence: 99%
“…Recent local studies have highlighted poor dietary practices and patterns among Malaysian children and adolescents, which have been linked to a poor quality of life [51][52][53] . Moreover, unhealthy dietary habits established at a young age are associated with an increased risk of cardiometabolic diseases and poor quality of life [52][53][54][55][56] . These age-, sex-and ethnic-specific variations in our SEACO-CH20 study highlight the importance of tailoring nutritional interventions to address the unique dietary preferences and cultural contexts of different ethnic communities.…”
Section: Discussionmentioning
confidence: 99%
“…Currently, there is a growing interest in assessing the potential significance of hematological pro-inflammatory markers for diagnosing and predicting various chronic conditions [62,63].…”
Section: Discussionmentioning
confidence: 99%
“…Gangguan tidur, seperti kurang tidur, kualitas tidur yang buruk, insomnia, dan sleep apnea obstruktif, merangsang produksi kortisol oleh korteks adrenal, memicu peningkatan asupan kalori dan penumpukan lemak pada anak-anak (Codazzi, Frontino, Galimberti, Giustina, & Petrelli, 2023). Data terkini menunjukkan bahwa sleep apnea berhubungan secara independen dengan faktor risiko kardiovaskular, termasuk sindrom metabolik, hipertensi, resistensi insulin, toleransi glukosa terganggu, dan dislipidemia (Nilsson et al, 2019).…”
Section: E Gangguan Tidurunclassified
“…Obesitas abdominal, yang sering ditunjukkan oleh lingkar pinggang yang besar, dan penimbunan lemak di organ hati, pankreas, dan otot rangka tampaknya memiliki dampak yang signifikan. Menurut Codazzi et al (2023), obesitas dan resistensi insulin saling terkait erat dalam patogenesis sindrom metabolik (Sindrom metabolik). Obesitas tanpa resistensi insulin tidak dapat menyebabkan sindrom metabolik.…”
Section: H Obesitasunclassified