Mechanisms and significance of spontaneous platelet aggregation in pathology

Abstract

Platelets are unique blood elements that, in addition to blood coagulation, modulate the processes of fibrinolysis, inflammation, physiological regeneration, repair, angiogenesis, bone tissue formation, formation of the mother-placenta-fetus system, etc. Of particular interest is the phenomenon of spontaneous platelet aggregation in vivo under various physiological and pathological conditions, which is associated with expanded capabilities for assessing the risks of thrombotic events. A separate aspect of this problem is associated with the study of the mechanisms and biological role of reversible platelet aggregation. To date, the significance of this phenomenon under normal and pathological conditions remains not entirely clear. This review is devoted to the phenomenon of spontaneous reversible platelet aggregation, the modern understanding of its mechanisms, approaches to its diagnosis and its association with various pathological conditions.