Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer

Jia, JunJun; Zhou, Xuelian; Chu, Qingfei

doi:10.1007/s11010-024-04983-5

Cited by 5 publications

(1 citation statement)

References 224 publications

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“…Jia et al presented a comprehensive overview of the JAK-STAT pathway, covering its composition, activation mechanisms, dynamic interactions, and the molecular drivers behind its abnormal activation in lung cancer (LC). They also highlighted recent advances in targeting this pathway for LC treatment, underscoring the necessity for further exploration into this promising therapeutic avenue [500]. Multiple investigations have demonstrated that the inability to upregulate PD-L1 and MHC-I expression leads to resistance to CTLA-4 and PD-1 inhibitors in instances of lost JAK/STAT signaling [493,498].…”

Section: Altered Signaling Pathwaysmentioning

confidence: 98%

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

Mitra,

Kumar,

Amdare

et al. 2024

Biology

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Cancer immune evasion represents a leading hallmark of cancer, posing a significant obstacle to the development of successful anticancer therapies. However, the landscape of cancer treatment has significantly evolved, transitioning into the era of immunotherapy from conventional methods such as surgical resection, radiotherapy, chemotherapy, and targeted drug therapy. Immunotherapy has emerged as a pivotal component in cancer treatment, harnessing the body’s immune system to combat cancer and offering improved prognostic outcomes for numerous patients. The remarkable success of immunotherapy has spurred significant efforts to enhance the clinical efficacy of existing agents and strategies. Several immunotherapeutic approaches have received approval for targeted cancer treatments, while others are currently in preclinical and clinical trials. This review explores recent progress in unraveling the mechanisms of cancer immune evasion and evaluates the clinical effectiveness of diverse immunotherapy strategies, including cancer vaccines, adoptive cell therapy, and antibody-based treatments. It encompasses both established treatments and those currently under investigation, providing a comprehensive overview of efforts to combat cancer through immunological approaches. Additionally, the article emphasizes the current developments, limitations, and challenges in cancer immunotherapy. Furthermore, by integrating analyses of cancer immunotherapy resistance mechanisms and exploring combination strategies and personalized approaches, it offers valuable insights crucial for the development of novel anticancer immunotherapeutic strategies.

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Section: Altered Signaling Pathwaysmentioning

confidence: 98%

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

Mitra,

Kumar,

Amdare

et al. 2024

Biology

View full text Add to dashboard Cite

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Circular RNAs and the JAK/STAT pathway: New frontiers in cancer therapeutics

Almalki,

Almujri

2024

Pathology - Research and Practice

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Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential

Li,

Huang

2024

Front. Cell Dev. Biol.

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Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among the top three in terms of incidence and mortality. Despite notable advancements in early detection and therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance and metastasis. Recent research has increasingly implicated the JAK-STAT signaling pathway as a pivotal contributor to CRC pathogenesis. This evolutionarily conserved pathway plays a key role in transmitting extracellular signals to the nucleus, thereby modulating gene expression involved in numerous fundamental biological processes. In CRC, dysregulation of the JAK-STAT pathway is frequently observed and is strongly associated with tumor progression, including processes such as cellular proliferation, apoptosis, metastasis, immune evasion, and the sustenance of cancer stem cells. Given its integral role in CRC advancement, the JAK-STAT pathway has gained recognition as a viable therapeutic target. Extensive evidence from preclinical and clinical models supports the efficacy and safety of targeting components of the JAK-STAT pathway, presenting new therapeutic possibilities for patients with CRC, particularly in addressing drug resistance and enhancing treatment outcomes. This review offers a detailed exploration of the JAK-STAT pathway, focusing on its regulatory mechanisms in CRC-related malignancies. Moreover, it examines the association between JAK-STAT protein expression, clinical features, prognosis, and its therapeutic potential in CRC management.

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Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer

Cited by 5 publications

References 224 publications

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

Circular RNAs and the JAK/STAT pathway: New frontiers in cancer therapeutics

Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential

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