2016
DOI: 10.3384/diss.diva-132640
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Mechanisms Behind Illness-Induced Anorexia

Abstract: Loss of appetite is together with fever and malaise hallmarks of infection. Loosing appetite during an acute infection such as influenza does not result in any long-lasting effects, but loosing appetite during chronic diseases such as cancer or AIDS constitutes a risk factor for mortality. Food intake regulation during inflammation is orchestrated by the brain in response to peripheral inflammatory signals. It is known that expression of the prostaglandin synthesizing enzyme cyclooxygenase 2 (COX-2) is crucial… Show more

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Cited by 2 publications
(1 citation statement)
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“…Decreased food consumption (anorexia) is the most common sign of infection and severe injury [20]. It is believed that IIA is an active host defense strategy for pathogen elimination and enhancing healing of injury [21][22][23]. Unlike the starvation-invoked regulatory mechanisms aim at conservation of protein mass in healthy subjects, patients with illness induced anorexia have increased energy expenditure and protein catabolism, associated with profound neuroendocrine alterations [23].…”
Section: Illness Induced Anorexia (Iia) Accompanying Upregulated Automentioning
confidence: 99%
“…Decreased food consumption (anorexia) is the most common sign of infection and severe injury [20]. It is believed that IIA is an active host defense strategy for pathogen elimination and enhancing healing of injury [21][22][23]. Unlike the starvation-invoked regulatory mechanisms aim at conservation of protein mass in healthy subjects, patients with illness induced anorexia have increased energy expenditure and protein catabolism, associated with profound neuroendocrine alterations [23].…”
Section: Illness Induced Anorexia (Iia) Accompanying Upregulated Automentioning
confidence: 99%