Mechanisms Behind the Increased Vulnerability of the Aging Stomach to NSAID-Related Injury: Perhaps Not As Simple As We May Think

Tang, Raymond; Chan, Francis K.L.

doi:10.1007/s10620-012-2443-6

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The vulnerability of aged mucosa on aspirin aggression [16] may be balanced by a decreased acid secretion in the gastric mucosa with gastric atrophy or/and intestinal metaplasia after longtime evolution of H. pylori infection [17] or by an increased mucosal tolerance to chronic drug exposure.…”

Section: Discussionmentioning

confidence: 99%

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers

Negovan

Iancu

Moldovan

et al. 2016

Gastroenterology Research and Practice

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Background. Aspirin use for cardiovascular or cancer prevention is limited due to its gastrointestinal side effects. Objective. Our prospective, observational case-control study aims to identify the predictive factors for ulcers in low-dose aspirin consumers (75–325 mg/day). Methods. The study included patients who underwent an upper digestive endoscopy and took low-dose aspirin treatment. Results. We recruited 51 patients with ulcer (ulcer group) and 108 patients with no mucosal lesions (control group). In univariate analysis, factors significantly associated with ulcers were male gender (p = 0.001), anticoagulants (p = 0.029), nonsteroidal anti-inflammatory drugs (p = 0.013), heart failure (p = 0.007), liver (p = 0.011) or cerebrovascular disease (p = 0.004), diabetes mellitus (p = 0.043), ulcer history (p = 0.044), and alcohol consumption (p = 0.018), but not Helicobacter pylori infection (p = 0.2). According to our multivariate regression analysis results, history of peptic ulcer (OR 3.07, 95% CI 1.06–8.86), cotreatment with NSAIDs (OR 8, 95% CI 2.09–30.58) or anticoagulants (OR 4.85, 95% CI 1.33–17.68), male gender (OR 5.2, 95% CI 1.77–15.34), and stroke (OR 7.27, 95% CI 1.40–37.74) remained predictors for ulcer on endoscopy. Conclusions. Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers

Negovan

Iancu

Moldovan

et al. 2016

Gastroenterology Research and Practice

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“…In their editorial, Tang and Chan [2] have already wisely commented upon these paradoxical findings by pointing out that the indomethacin-induced increase in PGE2 levels may be a transient phenomenon, possibly related to upregulation of COX-2 expression, and suggesting that, after all, the age-related decline in mucosal defences may not be entirely PGE2-dependent.…”

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confidence: 99%

Increased Vulnerability of the Aging Stomach to NSAIDs

Guslandi

2013

Dig Dis Sci

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Mechanisms Behind the Increased Vulnerability of the Aging Stomach to NSAID-Related Injury: Perhaps Not As Simple As We May Think

Cited by 2 publications

References 19 publications

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers

Increased Vulnerability of the Aging Stomach to NSAIDs

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