“…In contrast, others have shown increased IL-6 production in mice (Azcona-Olivera et al, 1995b;Dong et al, 1994;Zhou et al, 1997;Kaiser et al, 2004;Pestka and Amuzie, 2008;Wan et al, 2013;Chung et al, 2003a;Shi and Pestka, 2006;Moon and Pestka, 2003b;Islam and Pestka, 2006). Interestingly, another set of studies in pigs and mice has demonstrated the obvious induction of IL-6 mRNA expression by DON after 2-4 h of treatment time, and the decrease thereafter (Azcona-Olivera et al, 1995b;Kinser et al, 2005;Doll et al, 2009b;Shi and Pestka, 2009). IFN-c levels were also elevated, similar with previous studies on humans and mice (Azcona-Olivera et al, 1995a;Zhou et al, 1997;Meky et al, 2001).…”