The low production efficiency of a single production method limits the commercial feasibility of methane hydrate exploitation. In this work, a new combination method of the ionic liquid and heat injection is proposed to study the effect of ionic liquids including 1-butyl-3-methylimidazole chloride (BMIMCl)/tetramethylammonium chloride (TMACl) on production characteristics of the methane hydrate reservoir. The results indicate that the hydrate production process is affected by the coupling of thermal, chemical, and seepage fields and ionic liquid properties. Except for the TMACl ionic liquid concentration of 20 wt %, the increasing injected temperature is not conducive to gas production. Moreover, the maximum gas production is obtained at the low injected temperature when the concentration of BMIMCl ionic liquid is 10 wt %, but this is reversed when the injected concentration is 20 wt %. And over 50% gas recovery efficiency can be obtained by injecting the TMACl/BMIMCl ionic liquid. In addition, both TMACl and BMIMCl ionic liquids are more suitable for low-concentration injection at lower temperatures, and the two injection methods are more suitable for reservoirs with hydrate saturation of no more than 30%.