MECHANISMS IN ENDOCRINOLOGY: Hypothalamic inflammation and nutrition

Araujo, Eliana P.; Moraes, João Carlos Silos; Cintra, Dennys Esper; Velloso, Lı́cio A.

doi:10.1530/eje-15-1207

Cited by 32 publications

(31 citation statements)

References 82 publications

(148 reference statements)

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“…Considering the composition of juçara pulp, which is abundant in anthocyanins, MUFAs, and PUFAs, we postulated that the anti-inflammatory effect of juçara reaches CNS at low doses (0.25%). Our hypothesis is supported by the result of previous studies showing that the consumption of MUFAs and PUFAs can reverse hypothalamic inflammation [ 26 , 29 , 30 ]. Moreover, despite the lack of information regarding the effect of anthocyanins on the hypothalamus, studies demonstrating their positive effect on other tissues indicated that anthocyanins also have an anti-inflammatory activity in CNS [ 31 , 32 ].…”

Section: Discussionsupporting

confidence: 87%

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

et al. 2018

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Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-κB) pathway rapidly activated through high-fat diets. Juçara is a berry rich in anthocyanins and unsaturated fatty acids, which prevents obesity and associated comorbidities. We evaluated the effect of different doses of freeze-dried juçara pulp on NF-κB pathway after the consumption of short-term high-fat diet. Male Wistar rats with ad libitum access to food and water were divided into four groups: Control diet (C), high-fat diet (HFC), high-fat diet with 0.25% juçara (HFJ 0.25%), and high-fat diet with 0.5% juçara (HFJ 0.5%). Energy intake and body weight gain were increased in HFC and HFJ 0.5% groups compared to C group. The hypothalamus weight reduced in the HFC group compared to C and HFJ 0.25% groups. Cytokines, MYD88, TRAF6, and pNF-κBp50 levels in the hypothalamus, serum triacylglycerol, LDL-cholesterol (LDL-C), and free fatty acid levels were improved in the HFJ 0.25% group. In summary, the HFJ 0.25% group had better protective effects than those in the HFJ 0.5%. Therefore, 0.25% juçara can be used to protect against central inflammation through the high-fat diet-induced NF-κB pathway.

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Section: Discussionsupporting

confidence: 87%

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

et al. 2018

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“…Moreover, the inhibition of hypothalamic FoxO1 expression in rats with diet-induced obesity improved insulin sensitivity, and reduced dietary intake, body mass, and insulinemia [21]. Thus, the role of MKP3 in this context is very important, because the hypothalamus is a key organ for the maintenance of energy homeostasis and FoxO1 deregulation occurs under conditions of metabolic syndrome, obesity and Type 2 diabetes mellitus (1)(2)(3).…”

Section: Discussionmentioning

confidence: 99%

“…The hypothalamus acts as an important structure for metabolic control by regulating energy homeostasis through stimuli from the endocrine system [1][2][3][4]. In this context, insulin is an important regulator of energy homeostasis triggering a complex network of interactions between intracellular proteins [3].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus

Rodrigues

Kuga

Muñoz

et al. 2017

Neuroscience Letters

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The mitogen-activated kinase phosphatase-3 (MKP-3) has gained great importance in the scientific community by acting as a regulator of the cell cycle through dephosphorylation of FoxO1, an important transcription factor involved in the insulin intracellular signaling cascade. When dephosphorylated and translocated to the nuclei, FoxO1 can promote the transcription of orexigenic neuropeptides (NPY/AgRP) in the hypothalamus, whereas insulin signaling is responsible for the disruption of this process. However, it is not understood if the hypothalamic activation of MKP-3 affects FoxO1 phosphorylation, and we hypothesized that MKP-3 overexpression reduces the capacity of the insulin signal to phosphorylate FoxO1. In the present study, we overexpressed the DUSP6 gene through an injection of adenovirus directly into the hypothalamic third ventricle of Swiss mice. The colocalization of the adenovirus was confirmed by the immunofluorescence assay. Then, MKP-3 overexpression resulted in a significant reduction of hypothalamic FoxO1 phosphorylation after insulin stimulation. This effect was independent of changes in Akt phosphorylation. Thus, the role of MKP-3 in the hypothalamus is closely associated with FoxO1 dephosphorylation and may provide a potential therapeutic target against hypothalamic disorders related to obesity and unbalanced food intake control.

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“…The hypothalamus is the most important region of the brain capable of control food intake and energy expenditure. Thus, a better understanding of proteins involved in the hypothalamic control of energy homeostasis is necessary, once this mechanism is considered the pathophysiology of obesity (Araujo, Moraes, Cintra, & Velloso, ; Velloso & Schwartz, ). Herein, our results demonstrated that acute exercise session could modulate the APPL1 signaling and PI3K subunit, and reduce the food intake.…”

Section: Discussionmentioning

confidence: 99%

Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice

Gaspar

Muñoz

Kuga

et al. 2019

Eur J of Neuroscience

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Adiponectin is an adipokine that acts in the control of energy homeostasis. The adaptor protein containing the pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif 1 (APPL1) is a key protein in the adiponectin signaling. The APPL1 mediates a positive effect on the insulin signaling through the interaction with the phosphoinositide 3-kinase (PI3K). Thus, the present study aimed to explore the effects of an acute physical exercise session on the hypothalamic adiponectin signaling. Firstly, using bioinformatics analysis, we found a negative correlation between hypothalamic APPL1 mRNA levels and food consumption in several strains of genetically diverse BXD mice. Also, the mice and the human database revealed a positive correlation between the levels of APPL1 mRNA and PI3K mRNA. At the molecular level, the exercised mice showed increased APPL1 and PI3K (p110) protein contents in the hypothalamus of Swiss mice. Furthermore, the exercise increases co-localization between APPL1 and PI3K p110 predominantly 3182 | GASPAR et Al.

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MECHANISMS IN ENDOCRINOLOGY: Hypothalamic inflammation and nutrition

Cited by 32 publications

References 82 publications

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus

Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice

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