2022
DOI: 10.1530/eje-21-1278
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MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism

Abstract: Transient congenital hypothyroidism (TCH) refers to congenital hypothyroidism which spontaneously resolves in the first few months or years of life. Currently, there is a paucity of reliable markers predicting TCH at diagnosis, and the diagnosis is established following withdrawal of levothyroxine therapy around 3 years of age. The incidence of TCH is increasing, and it is a major contributor to the overall increase in incidence of CH in recent studies. Both genetic factors, in particular mutations affecting D… Show more

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Cited by 13 publications
(4 citation statements)
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“…13,14 Well-recognised causes of transient hypothyroidism in early life include abnormalities of the DUOX system but also maternal antibody transfer (Table 1). 15 There is now greater recognition of thyroid dysfunction arising because of exposure to iodine-containing cleansing and radiographic agents. 16 Whilst neonatal units in the United Kingdom are advised to avoid using iodine-containing compounds for procedures such as umbilical venous catheter (UVC) or umbilical arterial catheter (UAC) insertion, it is still considered a problem elsewhere in the world.…”
Section: Transient Primary Chtmentioning
confidence: 99%
“…13,14 Well-recognised causes of transient hypothyroidism in early life include abnormalities of the DUOX system but also maternal antibody transfer (Table 1). 15 There is now greater recognition of thyroid dysfunction arising because of exposure to iodine-containing cleansing and radiographic agents. 16 Whilst neonatal units in the United Kingdom are advised to avoid using iodine-containing compounds for procedures such as umbilical venous catheter (UVC) or umbilical arterial catheter (UAC) insertion, it is still considered a problem elsewhere in the world.…”
Section: Transient Primary Chtmentioning
confidence: 99%
“…Maternal transfer of thyroidstimulating hormone receptor-blocking autoantibodies (TBAbs) is a rare cause of transient CH, generally resolving within 3-6 months. 12 Newborn thyroid screening tests are established in most of the developed countries and are usually carried out on the second to third day of life. Screening programmes and cut-off levels of thyroidstimulating hormone (TSH) or either total or free thyroxine levels for the detection of CH vary in different countries, affecting the incidence of the disease and the management of the patients in each country.…”
Section: Introductionmentioning
confidence: 99%
“…Transient CH commonly resolves in the first few months or years of life. Maternal transfer of thyroid‐stimulating hormone receptor‐blocking autoantibodies (TBAbs) is a rare cause of transient CH, generally resolving within 3–6 months 12 …”
Section: Introductionmentioning
confidence: 99%
“…The majority of patients with CH need lifelong substitution with tyroxine, which is referred to as permanent CH (pCH), however, in a significant number of patients, thyroid function recovers in early childhood. These patients are the so-called transient CH (tCH) [12].…”
Section: Introductionmentioning
confidence: 99%