Mechanisms in genetic diseases of man

Response to Atropine in Down's Syndrome

“…The total dose of atropine given to our adult patients with Down's syndrome ranged from 1-4 to 3 0 mg (mean of 2-33 mg), and there were no disorders of cardiac rhythm, no systemic side effects, other than dry mouth and facial erythema. (McKusick, 1957). Both Priest (1960) and Berg et al (1959) comment on the lack of side effects to atropine used for preanaesthetic medication in patients with Down's syndrome.…”