Mechanisms Involved in the Alteration of Serum Copper Levels after Roux-en-Y Gastric Bypass Surgery (RYGB)

Lee, Jennifer; Oweis, Emil; Shope, Timothy; Finelli, Frederick C.; Koch, Timothy R.

doi:10.14309/00000434-201210001-00304

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conclusion, hypercupremia may occur after vertical sleeve gastrectomy and after RYGB. This finding stands in contrast to reports of hypocupremia after RYGB [3, 4]. Use of a daily copper-free multivitamin with mineral supplement and instruction on a low copper diet are reasonable initial approaches for the treatment of hypercupremia.…”

Section: Discussioncontrasting

confidence: 83%

“…In a report describing hypocupremia in individuals who had undergone Roux-en-Y gastric bypass (RYGB) surgery, Gletsu-Miller and associates also included identification of hypercupremia in 10 of 136 subjects (for a prevalence of 7.4%) [3]. In a retrospective review of 54 subjects after RYGB, we identified hypercupremia in 19% of individuals at 18 months or longer after RYGB surgery, but in only 8% of individuals at less than 18 months after RYGB surgery [4]. At that time we speculated that the likely origin for identification of hypercupremia after RYGB was the result of joint national practice guidelines recommending two multivitamins with minerals daily for postbariatric surgery patients [5], which would supply 4 mg of copper daily.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc

Koch

Zubowicz

Gross

2019

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

A 30-year-old female underwent vertical sleeve gastrectomy. Postoperatively, hypercupremia and elevated ceruloplasmin were identified. Further testing revealed normal blood levels of transaminases, alkaline phosphatase, and albumin. She stopped ingestion of multivitamins, began a copper-free multivitamin, and then began a low copper diet, but with no improvement in hypercupremia. Protein electrophoresis was normal with no M-spike. Urinary copper excretion was normal at 0.24 micromol/24 hours (normal: < 0.55), and there were no Kayser-Fleischer rings on slit lamp examination. Two years postoperatively, she lost 44% of excess preoperative weight and she began zinc sulfate before meals twice daily (115 mg elemental Zinc/day). At 2 months and 8 months later, plasma copper and ceruloplasmin had essentially normalized. Increased production of ceruloplasmin could have been a response to significant weight loss or the presence of nonalcoholic steatohepatitis. The mechanism of zinc’s beneficial effect is uncertain but may be related to suppressing hepatic synthesis of or secretion of ceruloplasmin.

show abstract

Section: Discussioncontrasting

confidence: 83%