Mechanisms involved in the development of Barrett’s esophagus: an experimental rat model

Richardson, J. David; Williams, Ruth; Ackermann, D. M.; Mh, Wheeler; Cornett, Daniel; Benjamin, Sylvia

doi:10.1093/dote/7.1.53

Cited by 2 publications

(3 citation statements)

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“…3, 22 There is counter‐evidence from the experimental development of a CLO‐like mucosa in the oesophagus of rats, although whether this represents a true metaplastic process is unclear. 16–18, 23 Also, like most small laboratory animals, rats do not have oesophageal glands and so it is difficult to derive a parallel between the pathogenesis of CLO in rats and that of humans. Most observations regarding the oesophageal gland ducts, and their relationship to Barrett's epithelium, in humans are based on the study of two‐dimensional histological sections in routine pathology.…”

Section: Discussionmentioning

confidence: 99%

“…In contradiction to the experimental evidence providing support for the oesophageal gland duct as the CLO precursor, rats can develop a CLO‐like mucosa of the lower oesophagus and yet they lack the submucosal gland ducts seen in canines and humans. 16–17 To date there has been a paucity of data derived from human tissue and animal models have provided the basis for the theories behind the histogenesis of CLO. However, it is unclear how closely these relate to the human mechanism of metaplastic transformation.…”

Section: Introductionmentioning

confidence: 99%

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On the histogenesis of Barrett's oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts

et al. 2005

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Current hypotheses concerning the histogenesis and regression of Barrett's oesophagus are based predominantly on animal models. Our study was formulated to assess, in human tissue, the morphological relationship between oesophageal gland ducts and both Barrett's oesophagus and their associated squamous islands. Serial sections were cut through a total of 46 blocks of archived oesophageal resection tissue containing oesophageal gland ducts underlying Barrett's epithelium. Serial sections were also taken through 15 squamous islands, taken from the same archived tissue, to assess their underlying histology: 21 of the ducts opened onto overlying Barrett's epithelium; in 17 there was a relatively sharp distinction between the two cell types, at the junction, whereas in four there was continuity and a gradual morphological change between the cells of the oesophageal gland ducts and the Barrett's epithelium. All 15 squamous islands sectioned were found to be continuous with an underlying gland duct. This study suggests an interrelationship between Barrett's epithelium and oesophageal gland ducts. More definitively we confirm that squamous islands are universally associated with oesophageal gland duct epithelium. These findings are of fundamental importance for the development of more targeted management strategies for Barrett's oesophagus. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On the histogenesis of Barrett's oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts

et al. 2005

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“…Further experimental rat animal models have suggested that the loss of supporting basement membrane is an important factor in producing columnar epithelium in rats. Richardson and colleagues, 20 in 1994, concluded that Barrett's epithelium arises from acid‐induced deep injury to the muscularis that is healed by a basal cell layer, which differentiates into a primitive columnar epithelium. Deep mucosal injury involving the muscularis mucosa, with removal of the subepithelial mesenchyme, in the presence of chronic gastroesophageal reflux, is necessary for migration of a basal cell layer, of gastric origin, to occur.…”

Section: Rat Modelsmentioning

confidence: 99%

Changing role ofin vivomodels in columnar-lined lower esophagus

Koak

Winslet

2002

Diseases of the Esophagus

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Columnar-lined lower esophagus (CLE) or Barrett's esophagus (BE) is caused by chronic reflux of the gastrointestinal tract and can progress to invasive adenocarcinoma. However, the pathophysiology, cell of origin, and management of this condition is incompletely understood. This review evaluates the role of in vivo models in resolving these debates. A search was performed on the Ovid and Pub Medline for 1964-2001 and Cochrane Collaboration. The keywords used were adenocarcinoma, animal model, Barrett's esophagus, columnar-lined esophagus, esophageal neoplasms, and esophageal carcinogenesis. All relevant papers were scrutinized and an attempt at tabulation was made. In vivo models have been used at several stages of debate on the pathophysiology of BE. They provide conclusive evidence for its acquired nature secondary to duodenogastroesophageal reflux. The cell of origin of experimental BE may arise from adjacent columnar epithelium, basal layer multipotent cells, or esophageal glands. Experimental work on BE is lacking in assessing therapeutic modalities.

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Mechanisms involved in the development of Barrett’s esophagus: an experimental rat model

Cited by 2 publications

References 0 publications

On the histogenesis of Barrett's oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts

On the histogenesis of Barrett's oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts

Changing role ofin vivomodels in columnar-lined lower esophagus

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