Mechanisms involved in the development of diabetic retinopathy induced by oxidative stress

Guzmán, David Calderón; Olguı́n, Hugo Juárez; García, Ernestina Hernández; Peraza, Armando Valenzuela; Cruz, Diego Zamora de la; Soto, Mónica Punzo

doi:10.1080/13510002.2016.1205303

Cited by 24 publications

(14 citation statements)

References 51 publications

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“…Retina is particularly susceptible to oxidative stress because of its high energy demands and exposure to light. Diabetic retinopathy is an eye disorder affecting the human retina due to prolonged hyperglycemia which causes defects in metabolic pathways in relation to the affected antioxidant systems, this increases the production of reactive oxygen species at the retinal level which finally worsens the diabetic complication [20]. Accumulation of reactive oxygen species contributes to the pathogenesis of diabetic retinopathy as well as to the resistance of diabetic retinopathy to reverse even after good glycemic control is achieved condition known as metabolic memory phenomenon [21,22].…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

2019

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The present study aimed to look for the differences in the oxidative stress status in sera and saliva samples of type 2 diabetic Iraqi patients with and without proliferative diabetic retinopathy. As well as to look for the possibility whether this status can be measured in saliva as an alternative sample to that of serum, hence to achieve that total oxidant status, total antioxidant status and oxidative stress index were measured in both sera and saliva samples of two groups of patients with type 2 diabetes mellitus and the healthy individuals. Upon the comparison between patients without proliferative diabetic retinopathy and the control sample the results showed presence of a significant increase (p < 0.05) of total oxidant status and oxidative stress index in sera and saliva samples, while there was a significant decrease (p < 0.05) in total antioxidant status of sera and saliva samples. Meanwhile when the comparison was done between patients with proliferative diabetic retinopathy and those without proliferative diabetic retinopathy, a significant increase (p < 0.05) in both salivary total oxidant status and oxidative stress index was observed with a significant decrease (p < 0.05) in sera and salivary total antioxidant status were found in the proliferative diabetic retinopathy patients group.

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Section: Resultsmentioning

confidence: 99%

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

2019

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“…The antioxidant status of a diabetic patient has an important role in producing oxidative stress and the development of vascular complications in patients with DM. The reports of antioxidants and antioxidant enzymes in DR patients are contradictory [4,5,6,18]. The total thiol levels as a marker of antioxidant status in diabetics has shown to be significantly decreased in patients with DR.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal tissue is rich in polyunsaturated fatty acids, is directly exposed to UV radiation and has high demand for energy, which makes it prone to oxidative stress. Oxidative stress is proven in patients with DM and is also important in the development of a microvascular complication of DMT2 [3][4][5][6].…”

Section: Association Of Advanced Oxidation Protein Product Thiobarbimentioning

confidence: 99%

Association of advanced oxidation protein product, thiobarbituric acid reactive substances and total sulfhydryl groups with retinal blood vessels caliber

et al. 2019

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Introduction/Objective Intensive oxidative stress is proven in patients with diabetes mellitus and important in the development of a microvascular complication of type 2 diabetes mellitus. The aim of the study was to investigate the relationship between morphometric parameters of retinal blood vessels in patients with diabetic retinopathy (DR) and the levels of parameters of oxidative stress: advanced oxidation protein product (AOPP), thiobarbituric acid reactive substances (TBARS), and total sulfhydryl (SH) groups in blood samples. Methods The patients (the group with DR and controls) were sex-and age-matched. Glycaemia, hemoglobin A1C HbA1C, total cholesterol and its fractions, and triglycerides were measured in blood samples. AOPP and total SH groups were determined in the plasma by specific methods. Modification of the thiobarbituric acid method was used for the determination of TBARS. The number and diameter of retinal blood vessels, as morphometric parameters on digital retinal photography, was determined by using the ImageJ software. Student's t-test was used as the statistical method for the evaluation of differences between the morphometric and blood test parameters. The significance of differences in morphometric parameters of retinal blood was establish by one-way ANOVA. Results Significantly higher levels of parameters of oxidative stress (AOPP and TBARS) were in the group of patients with DR than in the controls. This difference was also present among the patients with mild and severe forms of DR (AOPP F 77.03, p < 0.001) (TBARS F 63.28, p < 0.001). The diameter of retinal blood vessels correlated with levels of AOPP, but only in patients with mild DR. Conclusion Parameters of oxidative stress, AOPP and TBARS, may be important for the follow-up of DR. In early stages in diabetic retinopathy, AOPP can be a valuable biomarker.

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“…Glaucoma and diabetes are known to stress retinal photoreceptors , and this could relate to the accelerated accumulation of focus‐positive rod cells in these conditions as compared to age‐adjusted controls. Interestingly, this focal telomere DNA expansion phenotype does not correlate with the previous finding that rod cells from nocturnal animals have a unique inverted pattern of heterochromatin, in contrast to diurnal animals, which display a conventional heterochromatic pattern where the nuclear periphery is enriched for heterochromatin and euchromatin resides toward interior of the nucleus .…”

Section: Discussionmentioning

confidence: 99%

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

et al. 2018

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We have identified a discrete, focal telomere DNA expansion phenotype in the photoreceptor cell layer of normal, non-neoplastic human retinas. This phenotype is similar to that observed in a subset of human cancers, including a large fraction of tumors of the central nervous system, which maintain their telomeres via the non-telomerase-mediated alternative lengthening of telomeres (ALT) mechanism. We observed that these large, ultra-bright telomere DNA foci are restricted to the rod photoreceptors and are not observed in other cell types. Additionally, focus-positive rod cells are dispersed homogeneously throughout the posterior retinal photoreceptor cell layer and appear to be human-specific. We examined 108 normal human retinas obtained at autopsy from a wide range of ages. These large, ultra-bright telomere DNA foci were not observed in infants before 6 months of age; however, the prevalence of focus-positive rod cells dramatically increased throughout life. To investigate associations between this phenotype and retinal pathology, we assessed adult glaucoma (N = 29) and diabetic retinopathy (N = 38) cases. Focus-positive rod cells were prominent in these diseases. When compared to the normal group, after adjusting for age, logistic regression modeling revealed significantly increased odds of falling in the high category of focus-positive rod cells for glaucoma and diabetic retinopathy. In summary, we have identified a dramatic telomere alteration associated with aging and diseases affecting the retina.

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Mechanisms involved in the development of diabetic retinopathy induced by oxidative stress

Abstract: The poor control of glucemy in pacients with DB has been shown contribute to the development of complications in eyes as DR.

Cited by 24 publications

References 51 publications

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

Association of advanced oxidation protein product, thiobarbituric acid reactive substances and total sulfhydryl groups with retinal blood vessels caliber

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

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