Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases

Mozoş, Ioana

doi:10.1155/2015/682054

Cited by 130 publications

(94 citation statements)

References 99 publications

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“…8 Aside from the earlier mentioned common genetic polymorphisms responsible for excess CKD and ESRD in African Americans, 9–13 there may be additional ones affecting cardiovascular pathophysiology and outcomes. 48–50 We limited our analysis to patients with eGFR≥60 in order to examine patients in whom clinical outcomes would be less likely affected by genetic differences leading to kidney disease and/or the biologic effect of azotemia, which could directly or indirectly affect the lower mortality previously described by us in African-American veterans with CKD. 15 Our results which show lower mortality and CHD incidence, but higher stroke incidence in African-Americans independent of their level of eGFR suggests that such differences could be a result of genetic or other differences in susceptibility to various cardiovascular processes.…”

Section: Discussionmentioning

confidence: 99%

Association of Race With Mortality and Cardiovascular Events in a Large Cohort of US Veterans

et al. 2015

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Background In the general population African-Americans experience higher mortality than their white peers, attributed, in part, to their lower socio-economic status, reduced access to care and possibly intrinsic biologic factors. A notable exception are patients with kidney disease, among whom African-Americans experience lower mortality. It is unclear if similar differences affecting outcomes exist in patients with no kidney disease but with similar access to health care. Methods and Results We compared all-cause mortality, incident coronary heart disease (CHD) and incident ischemic stroke using multivariable adjusted Cox models in a nationwide cohort of 547,441 African-American and 2,525,525 white patients with baseline estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73m2 receiving care from the US Veterans Health Administration. In parallel analyses we compared outcomes in African-American vs. white individuals in the National Health and Nutrition Examination Survey 1999–2004 (NHANES). After multivariable adjustments in veterans, African-American race was associated with 24% lower all-cause mortality (adjusted hazard ratio (aHR), 95% confidence interval (CI): 0.76, 0.75–0.77, p<0.001) and 37% lower incidence of CHD (aHR, 95%CI: 0.63, 0.62–0.65, p<0.001), but similar incidence of ischemic stroke (aHR, 95%CI: 0.99, 0.97–1.01, p=0.3). African-American race was associated with a 42% higher adjusted mortality among individuals with eGFR≥60 ml/min/1.73m2 in NHANES (aHR, 95%CI: 1.42 (1.09–1.87)). Conclusions African-American veterans with normal eGFR have lower all-cause mortality and incidence of CHD, and similar incidence of ischemic stroke. These associations are in contrast with the higher mortality experienced by African-American individuals in the general US population.

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Section: Discussionmentioning

confidence: 99%

Association of Race With Mortality and Cardiovascular Events in a Large Cohort of US Veterans

et al. 2015

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“…In most cases, the investigated patient cohorts were divided according to the median or the quartiles of the investigated population, which yielded different cut-off values. Taken together, an elevated RDW could be proven to be an independent and powerful predictor for adverse events in a large number of clinical settings, i.e., in patients suffering from cardiovascular diseases or septic shock 13,[17][18][19] . There are also some very interesting and well-performed studies, which have focused on the impact of RDW estimation at the time point of ICU admission in terms of its mortality predicting value.…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and survival in patients hospitalized on a medical ICU

Fujita

Franz

Figulla

et al. 2015

Clinical Biochemistry

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“…The cardiovascular effects of SCD and thalassemia are due to iron accumulation and hypoxia, respectively. The risk of thromboembolism should be assessed after splenectomy in the case of congenital chronic hemolytic anemia [50].…”

Section: Diseases Of Erythrocytesmentioning

confidence: 99%

Effects of Therapeutic and Toxic Agents on Erythrocytes of Different Species of Animals

Saganuwan¹

2019

Erythrocyte

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A preponderance of therapeutic and toxic agents that affect erythrocytes is being used in preclinical and clinical settings. Such agents are responsible for wrong diagnosis of a myriad of diseases and poor prognosis of some therapeutic interventions. In view of this, literature search was carried out with a view to investigate morphometry of erythrocytes in various diseased conditions and species of animals. Findings have shown that erythrocyte size, area, and volume vary in different species of animals under different diseased conditions. Environmental factors, toxicants, toxins, therapeutics, and management system, among others, can cause erythrocyte deformation, leading to anemia. Erythrocyte-related diseases include but not limited to sickle cell anemia, malaria, cancer, psychiatric illness, and chronic inflammation. Hence the principal source of our survival is erythrocyte, because it transports oxygen needed for metabolism of cell nutrients. erythrocytes (4.2-6.2 Â 10 12 /L), hemoglobin (100 g/100 mL), and hematocrit (38-54%) of the total blood volume are the standards for human species [12]. Variation in species, age, environmental factors, management system, and pathological conditions could affect the size, shape, area, and volume of erythrocytes. MethodologyExtensive literature search was carried out to identify differences between normal and abnormal erythrocytes of various species of animals including the ones in the wild. Information on beneficial and toxic effects of drugs, chemical toxicants, toxins, plant extracts, chemicals, and diseased conditions were searched on erythrocyte shape, size, and volume for various species of animals including human. Some developed formulas were modified for determination of anemic, polycythemic, hydrated, and dehydrated erythrocytes. Physiological and pathological features of the erythrocytes were also highlighted. Preclinical and clinical values of the changes in erythrocytes in relation to blood diseases caused by various agents were critically analyzed. Effects of toxic and therapeutic agents on metabolic, cancer, infectious, inheritable, and noninheritable diseases of erythrocytes, such as sickle cell anemia, malaria, and hereditary spherocytosis, among others, were elucidated. Erythrocyte

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Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases

Cited by 130 publications

References 99 publications

Association of Race With Mortality and Cardiovascular Events in a Large Cohort of US Veterans

Association of Race With Mortality and Cardiovascular Events in a Large Cohort of US Veterans

Red cell distribution width and survival in patients hospitalized on a medical ICU

Effects of Therapeutic and Toxic Agents on Erythrocytes of Different Species of Animals

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