Mechanisms of action and synergetic formulas of plant-based natural compounds from traditional Chinese medicine for managing osteoporosis: a literature review

Zhou, Chengcong; Shen, Shuchao; Zhang, Muxin; Luo, Huan; Zhang, Yuliang; Wu, Chengliang; Zeng, Lingfeng; Ruan, Hongfeng

doi:10.3389/fmed.2023.1235081

Cited by 4 publications

(1 citation statement)

References 170 publications

(168 reference statements)

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“…Phytochemical treatments have been used to induce OB differentiation in in vitro models ( Pan et al, 2005 ; Shakibaei et al, 2012 ; Zhou et al, 2015 ; Martiniakova et al, 2022 ; Shen et al, 2022 ; Zhou et al, 2023 ). The combination of Que with other bioactive ingredients has shown synergistic anti-osteoporotic effects ( Rayalam et al, 2011 ).…”

Section: Effects Of Que In Combination With Other Phytochemicalsmentioning

confidence: 99%

Pharmacological and mechanistic aspects of quercetin in osteoporosis

Deng,

Ding,

et al. 2024

Front. Pharmacol.

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Osteoporosis (OP) is a bone disease associated with increasing age. Currently, the most common medications used to treat OP are anabolic agents, anti-resorptive agents, and medications with other mechanisms of action. However, many of these medications have unfavorable adverse effects or are not intended for long-term use, potentially exerting a severe negative impact on a patient’s life and career and placing a heavy burden on families and society. There is an urgent need to find new drugs that can replace these and have fewer adverse effects. Quercetin (Que) is a common flavonol in nature. Numerous studies have examined the therapeutic applications of Que. However, a comprehensive review of the anti-osteoporotic effects of Que has not yet been conducted. This review aimed to describe the recent studies on the anti-osteoporotic effects of Que, including its biological, pharmacological, pharmacokinetic, and toxicological properties. The outcomes demonstrated that Que could enhance OP by increasing osteoblast differentiation and activity and reducing osteoclast differentiation and activity via the pathways of Wnt/β-catenin, BMP/SMAD/RUNX2, OPG/RANKL/RANK, ERK/JNK, oxidative stress, apoptosis, and transcription factors. Thus, Que is a promising novel drug for the treatment of OP.

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Section: Effects Of Que In Combination With Other Phytochemicalsmentioning

confidence: 99%

Pharmacological and mechanistic aspects of quercetin in osteoporosis

Deng,

Ding,

et al. 2024

Front. Pharmacol.

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Efficacy and safety of traditional Chinese medicine in managing bone loss post-endocrine therapy in hormone receptor-positive breast cancer patients

Chen,

Zhang,

et al. 2024

Medicine

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Background: This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) kidney-tonifying methods in treating bone loss and osteoporosis following endocrine therapy in patients with hormone receptor-positive breast cancer. Methods: This research systematically searched 6 major medical electronic databases, initially identifying 986 articles, ultimately including 22 randomized controlled trials. These studies encompassed a total of 1579 patients and investigated the impact of TCM kidney-tonifying methods on lumbar spine bone density, lumbar spine bone density T-values, femoral neck bone density, clinical efficacy, and drug safety. The Cochrane quality scoring system was utilized to assess the quality of the literature, and data were synthesized using meta-analysis techniques. Results: TCM kidney-tonifying methods significantly improved lumbar spine bone density (standardized mean difference [SMD] = 0.70, 95% confidence interval [CI]: 0.43–0.97) and lumbar spine bone density T-values (SMD = 1.012, 95% CI: 0.506–1.517). There was also a positive trend in enhancing femoral neck bone density (SMD = 0.645, 95% CI: 0.321–0.970). Although improvements in clinical efficacy did not reach statistical significance (relative risk [RR] = 1.122, 95% CI: 0.933–1.348), the studies indicated good safety of the treatment, with most studies reporting no significant adverse reactions. Conclusion: TCM kidney-tonifying methods may have a positive therapeutic effect on bone loss and osteoporosis following endocrine therapy in patients with hormone receptor-positive breast cancer, demonstrating good tolerability and safety. Given the current evidence, it is recommended to include TCM kidney-tonifying methods as a complementary therapeutic approach in treatment protocols. Future research should further validate these findings and explore their application in different patient subgroups.

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Osteoporosis treatment: current drugs and future developments

Chen,

Jia,

Han

et al. 2024

Front. Pharmacol.

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Osteoporosis is a common systemic metabolic disease characterized by a decrease in bone density and bone mass, destruction of bone tissue microstructure, and increased bone fragility leading to fracture susceptibility. Pharmacological treatment of osteoporosis is the focus of current research, and anti-osteoporosis drugs usually play a role in inhibiting bone resorption, promoting bone formation, and having a dual role. However, most of the drugs have the disadvantages of single target and high toxic and side effects. There are many types of traditional Chinese medicines (TCM), from a wide range of sources and mostly plants. Herbal plants have unique advantages in regulating the relationship between osteoporosis and the immune system, acupuncture therapy has significant therapeutic effects in combination with medicine for osteoporosis. The target cells and specific molecular mechanisms of TCM in preventing and treating osteoporosis have not been fully elucidated. At present, there is a lack of comprehensive understanding of the pathological mechanism of the disease. Therefore, a better understanding of the pathological signaling pathways and key molecules involved in the pathogenesis of osteoporosis is crucial for the design of therapeutic targets and drug development. In this paper, we review the development and current status of anti-osteoporosis drugs currently in clinical application and under development to provide relevant basis and reference for drug prevention and treatment of osteoporosis, with the aim of promoting pharmacological research and new drug development.

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Mechanisms of action and synergetic formulas of plant-based natural compounds from traditional Chinese medicine for managing osteoporosis: a literature review

Cited by 4 publications

References 170 publications

Pharmacological and mechanistic aspects of quercetin in osteoporosis

Pharmacological and mechanistic aspects of quercetin in osteoporosis

Efficacy and safety of traditional Chinese medicine in managing bone loss post-endocrine therapy in hormone receptor-positive breast cancer patients

Osteoporosis treatment: current drugs and future developments

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