Mechanisms of action of
            <i>Lycium barbarum</i>
            polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway

Peng, Liqian; Lu, Yue; Gu, Ye; Liang, Bihua; Li, Yanhong; Li, Huaping; Ke, Yanan; Chen, Jiaoquan; Li, Zhenjie

doi:10.1080/13880209.2022.2163406

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…The monobenzone-induced vitiligo model primarily focuses on melanocyte apoptosis and is well suited for studying molecular and cellular mechanisms related to this process [ 40 , 41 , 42 ]. However, compared to models induced by autoimmune mechanisms, there is an obvious lack of autoimmune components attacking melanocytes in the monobenzone-induced model, potentially leading to fully replicating the complexity of immune abnormalities observed in vitiligo patients [ 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Luo,

Meng,

et al. 2024

IJMS

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Vitiligo is a complex skin disorder that involves oxidative stress and inflammatory responses and currently lacks a definitive cure. Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive method for targeting the auricular branch of the vagus nerve and has gained widespread attention for potential intervention in the autonomic nervous system. Although previous research has suggested that vagus nerve stimulation can potentially inhibit inflammatory responses, its specific role and mechanisms in vitiligo treatment remain unknown. This study aimed to explore the therapeutic effects of taVNS in a mouse model of vitiligo induced by monobenzone. Initially, a quantitative assessment of the treatment effects on vitiligo mice was conducted using a scoring system, revealing that taVNS significantly alleviated symptoms, particularly by reducing the depigmented areas. Subsequent immunohistochemical analysis revealed the impact of taVNS treatment on melanocyte granules, mitigating pigment loss in the skin of monobenzone-induced vitiligo mice. Further analysis indicated that taVNS exerted its therapeutic effects through multiple mechanisms, including the regulation of oxidative stress, enhancement of antioxidant capacity, promotion of tyrosine synthesis, and suppression of inflammatory responses. The conclusions of this study not only emphasize the potential value of taVNS in vitiligo therapy, but also lay a foundation for future research into the mechanisms and clinical applications of taVNS.

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Section: Discussionmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Luo,

Meng,

et al. 2024

IJMS

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“…In addition, Peng has revealed that Lycium barbarum polysaccharide (LBP) protected keratinocytes and fibroblasts against oxidative stress. It was speculated that this protective effect might be attributed to regulating the STAT3-Hsp70-CXCL9/CXCL10 pathway ( 66 ).…”

Section: The Role Of Dermal Fibroblasts In Autoimmune Skin Diseasesmentioning

confidence: 99%

The role of dermal fibroblasts in autoimmune skin diseases

Shi,

Liu,

Wei

et al. 2024

Front. Immunol.

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Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various dermatological conditions such as psoriasis, vitiligo, and atopic dermatitis. Recently, variations in the subtypes of fibroblasts and their expression profiles have been identified in these prevalent autoimmune skin diseases, implying that fibroblasts may exhibit distinct functionalities across different diseases. In this review, from the perspective of their fundamental functions and remarkable heterogeneity, we have comprehensively collected evidence on the role of fibroblasts and their distinct subpopulations in psoriasis, vitiligo, atopic dermatitis, and scleroderma. Importantly, these findings hold promise for guiding future research directions and identifying novel therapeutic targets for treating these diseases.

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“…For instance, studies have displayed that HSP70 mRNA expression is significantly enhanced in diseased skin biopsies of vitiligo patients than in non-focal skin biopsies of vitiligo patients [23]. In addition, LBP can protect keratinocytes from oxidative stress through CXCL9/CXCL10 pathway by downregulating the expression of Hsp70 [24].…”

Section: Innate Immunitymentioning

confidence: 99%

Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity

Tingting Yu,

Yan Wu,

Zhenzhong Lu

2024

Cell Mol Biol (Noisy-le-grand)

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Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway

Cited by 8 publications

References 26 publications

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

The role of dermal fibroblasts in autoimmune skin diseases

Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity

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