2007
DOI: 10.1016/j.toxlet.2006.10.022
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms of action of the carcinogenic heterocyclic amine PhIP

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
28
0

Year Published

2007
2007
2022
2022

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 37 publications
(31 citation statements)
references
References 22 publications
3
28
0
Order By: Relevance
“…The mechanistic basis of this is thought to be the CYP1-mediated oxidation to the N-hydroxy derivative (primarily catalyzed by CYP1A2; ref. 10) and then the esterification resulting in an unstable product that generates a nitrenium ion that attacks and adducts to guanine in DNA (11,12). Yet treatment of CYP1A2-null mice with PhIP still results in carcinogenesis (13), probably via CYP1A1 and CYP1B1 oxidative activation of the compound (14).…”
Section: Introductionmentioning
confidence: 99%
“…The mechanistic basis of this is thought to be the CYP1-mediated oxidation to the N-hydroxy derivative (primarily catalyzed by CYP1A2; ref. 10) and then the esterification resulting in an unstable product that generates a nitrenium ion that attacks and adducts to guanine in DNA (11,12). Yet treatment of CYP1A2-null mice with PhIP still results in carcinogenesis (13), probably via CYP1A1 and CYP1B1 oxidative activation of the compound (14).…”
Section: Introductionmentioning
confidence: 99%
“…À10 mol/L), PhIP is able to stimulate proliferation in estrogen receptor-positive human mammary carcinoma MCF-7 cells in a manner that is inhibited by the antiestrogen ICI 182,780 (19,51,52). More recently, Nakai et al (53) reported that whereas PhIP treatment of Big Blue rats resulted in increased mutation frequencies in all lobes of the prostate, increased proliferation was only observed in the ventral lobe, the area where PhIP specifically induces prostate cancer.…”
mentioning
confidence: 99%
“…Cooking fish and beef inevitably generate HCA especially at high temperatures (Schut et al, 1999), which are carcinogenic in mice, rats and monkeys producing hepatic, intestinal and mammary tumours (Schoeffner and Thorgeirsson, 2000) and posing a potential risk to humans. HCA have been widely investigated and all of them have so far been described as mutagenic and carcinogenic (Gooderham et al, 2007). Food-derived heterocyclic amines (HCA) like IQ have been shown to be mutagenic in the Ames test inducing gene mutations and tumours in vivo (Adamson and Thorgeirsson, 1995;Knize et al, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…IQ and PhIP were shown to be potent genotoxins and carcinogens (Adamson et al, 1995;Durling and Abramsson-Zetterberg, 2005;Duthie et al, 1997). Even very low doses (10 -3 to 10 -4 µM PhIP) induce expression of the DNA damage response proteins like p53 and increase proliferation in oestrogen receptor (ER)-negative MCF10A cells (Gooderham et al, 2007). Hence, PhIP may induce/enhance carcinogenicity via DNA damage and/or oestrogen receptors (Bennion et al, 2005;Felton et al, 2004).…”
Section: The Effect Of Flavonoids In Soybean Products In Lymphocytes mentioning
confidence: 99%