Mechanisms of acute and chronic pain after surgery

Pogatzki-Zahn, Esther; Segelcke, Daniel; Zahn, Peter

doi:10.1097/aco.0000000000000646

Cited by 46 publications

(23 citation statements)

References 92 publications

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“…For example, our previous studies used a hot water tail immersion test as an acute thermal pain model and complete Freund's adjuvant (CFA)-induced inflammation pain as a chronic pain model (Li, Shah, Patel, Rice, & France, 2013;Siemian, Jia, Liu, Zhang, & Li, 2018). Certain drug targets may participate in acute and chronic pain differently due to their mechanistic differences (Pogatzki-Zahn, Segelcke, & Zahn, 2018). Given the essential role of opioids in pain management, it is important to examine whether TA 1 receptor antagonists would change the analgesic effects of opioids.…”

Section: Introductionmentioning

confidence: 99%

Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Liu

Seaman

Johnson

et al. 2021

British J Pharmacology

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Background and Purpose Trace amine‐associated https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptors play critical roles in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptors modulates addiction‐like behaviours associated with psychostimulants. However, little is known about whether https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptor modulation would regulate the behavioural effects of opioids. Experimental Approach Effects of the selective https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptor partial agonist RO5263397 on the addiction‐related and antinociceptive effects of morphine were systematically assessed in male rats and mice. Key Results RO5263397 attenuated the expression of morphine‐induced behavioural sensitization in wildtype but not https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptor knockout mice. RO5263397 shifted the dose‐effect curve of morphine self‐administration downward and reduced the breakpoint in a progressive ratio schedule of reinforcement but did not affect food self‐administration in rats. RO5263397 decreased the cue‐ and drug‐induced reinstatement of morphine‐seeking behaviour in rats. RO5263397 alone did not trigger reinstatement of morphine‐seeking behaviour or change locomotor activity in rats with a history of morphine self‐administration. However, RO5263397 did not affect the expression of morphine‐induced conditioned place preference in mice or rats. RO5263397 did not affect naltrexone‐precipitated jumping behaviour or naltrexone‐induced conditioned place aversion in morphine‐dependent mice. Furthermore, RO5263397 did not affect the analgesic effects of morphine in an acute nociception model in mice and a chronic pain model in rats. Conclusion and Implications These results indicated that https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptor activation selectively attenuated the reinforcing, but not withdrawal or antinociceptive effects of morphine, suggesting that selective https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3641 receptor agonists might be useful to combat opioid addiction, while sparing the analgesic effects.

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Section: Introductionmentioning

confidence: 99%

Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Liu

Seaman

Johnson

et al. 2021

British J Pharmacology

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“…Many mechanisms have been investigated. Most recent research focused on opioid-induced hyperalgesia and endogenous descending inhibition ( Pogatzki-Zahn et al, 2018 ). In this study, we found that plantar incision in mice enhanced responsiveness to mechanical and thermal stimuli, which are indicative of primary mechanical allodynia and thermal hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice

Liu

Wei

et al. 2020

Front. Neurosci.

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Poor postoperative pain (POP) control increases perioperative morbidity, prolongs hospitalization days, and causes chronic pain. However, the specific mechanism(s) underlying POP is unclear and the identification of optimal perioperative treatment remains elusive. Akt and mammalian target of rapamycin (mTOR) are expressed in the spinal cord, dorsal root ganglion, and sensory axons. In this study, we explored the role of Akt and mTOR in pain-related behaviors induced by plantar incision in mice. Plantar incision activated spinal Akt and mTOR in a dose-dependent manner. Pre-treatment with Akt inhibitors intrathecally prevented the activation of mTOR dose-dependently. In addition, blocking the Akt-mTOR signaling cascade attenuated pain-related behaviors and spinal Fos protein expression induced by plantar incision. Our observations demonstrate that Akt-mTOR might be a potential therapeutic target for the treatment of POP.

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“…Inflammatory pain was the first type of pathological pain to be modeled in rodent studies, by the administration of different inflammatory compounds such as brewer's yeast, which was used as early as 1957 (Randall and Selitto, 1957). Subsequently, several other agents were used to induce painful inflammation, and this was followed by the development of different animal models designed to cover a wide repertoire of clinically relevant pain conditions, including neuropathic, osteoarthritis, cancer or postoperative pain (Wang and Wang, 2003;Sisignano et al, 2014;Challa, 2015;Muley et al, 2016;Pogatzki-Zahn et al, 2018;O'Brien et al, 2017).…”

Section: The Development Of Pathological Pain Models and The Assessmementioning

confidence: 99%

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

González‐Cano

Montilla-García

Ruiz-Cantero

et al. 2020

Neuroscience & Biobehavioral Reviews

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Mechanisms of acute and chronic pain after surgery

Abstract: Pathophysiological mechanisms of pain after surgery are increasingly discovered, but utilization of pain behavior assays are only sparsely able to reflect clinical-relevant aspects of acute and chronic postoperative pain in patients.

Cited by 46 publications

References 92 publications

Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

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