Mechanisms of adaptation of the hypothalamic-pituitary-adrenal axis in male mice under chronic social defeat stress
А. А. Sapronova,
Y. A. Ryabushkina,
P. E. Kisaretovа
et al.
Abstract:The hypothalamic-pituitary-adrenal axis (HPA) plays an important role in the mechanisms of adaptation to chronic stress. A model of chronic social defeat stress (CSDS), based on the experience of defeat in daily agonistic interactions, causes the development of a depressive-like state in mice, which is often accompanied by an increase in blood corticosterone levels. In this work, we assessed what changes occur in the central (hypothalamus) and peripheral (adrenal glands) parts of the HPA axis under the influen… Show more
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