Mechanisms of adaptive supersensitivity in vas deferens

Quintas, Luis Eduardo M.; Noël, François

doi:10.1016/j.autneu.2009.01.002

Cited by 11 publications

(4 citation statements)

References 96 publications

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“…Studies of the molecular phenotype of W mutants, displaying and not displaying cholinergic and nitrergic responses, are lacking, but the fact that purinergic responses (Sergeant et al 2002) and non‐cholinergic excitatory responses (Huizinga et al 2008) are up‐regulated in W mutants makes the issue of neuromuscular remodelling an intriguing hypothesis to investigate. Denervation supersensitivity is a well‐known phenomenon in visceral smooth muscles (Auintas & Noel, 2009). The developing gut may compensate, to some extent, for loss of motor innervation in the absence of ICC.…”

Section: Functional Defects In Neurotransmission From Losing Iccmentioning

confidence: 99%

Neuroeffector apparatus in gastrointestinal smooth muscle organs

Sanders

Hwang

Ward

2010

The Journal of Physiology

134

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Section: Functional Defects In Neurotransmission From Losing Iccmentioning

confidence: 99%

Neuroeffector apparatus in gastrointestinal smooth muscle organs

Sanders

Hwang

Ward

2010

The Journal of Physiology

134

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“…The vas deferens store mature spermatozoa and is responsible for dispersing sperm into the urethra to be combined with other components of sperm prior to ejaculation. The sympathetic nerve-vas deferens preparation, introduced by Huković in [171] has been used as a model to study autonomic neuromuscular transmission ([64,65]; see [60,67,331,435]). …”

Section: Vas Deferensmentioning

confidence: 99%

Purinergic signalling in the reproductive system in health and disease

Burnstock

2013

Purinergic Signalling

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There are multiple roles for purinergic signalling in both male and female reproductive organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves, contracts smooth muscle via P2X1 receptors in vas deferens, seminal vesicles, prostate and uterus, as well as in blood vessels. Male infertility occurs in P2X1 receptor knockout mice. Both short-and long-term trophic purinergic signalling occurs in reproductive organs. Purinergic signalling is involved in hormone secretion, penile erection, sperm motility and capacitation, and mucous production. Changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain.

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“…The plexus formed by the sympathetic nerves represent the main excitatory component of the vas deferens (Quintas & Noël, 2009), and noradrenaline and ATP are the principal mediators co-released after nerve stimulation (Sneddon & Westfall, 1984). Electric-eld stimulation (EFS) causes a biphasic muscular contraction, with an initial purinergic component (ATP), followed by an adrenergic (noradrenaline) component .…”

Section: Introductionmentioning

confidence: 99%

6-Nitrodopamine potentiates contractions of rat isolated vas deferens induced by noradrenaline, adrenaline, dopamine and electric field stimulation

Britto-Júnior

Lima

Campos

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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6-nitrodopamine (6-ND) is a novel endogenous catecholamine that is released from rat isolated vas deferens, and it has been characterized as a major modulator of the contractility of rat isolated epididymal vas deferens (RIEVD). Drugs such as tricyclic antidepressants, a 1 and b 1 b 2 adrenoceptor blockers, act as selective antagonists of the 6-ND receptor in the RIEVD. In the rat isolated atria, 6-ND has a potent positive chronotropic action and causes remarkable potentiation of the positive chronotropic effects induced by dopamine, noradrenaline, and adrenaline. Here it was investigated whether 6-ND interacts with the classical catecholamines in the rat isolated vas deferens.Incubation with 6-ND (0.1 and 1nM; 30min) caused no contractions in the RIEVD but provoked signi cant leftward shifts in the concentration-response curves to noradrenaline, adrenaline, and dopamine. Preincubation of the RIEVD with 6-ND (1nM), potentiated the contractions induced by electric-eld stimulation (EFS), whereas pre-incubation with 1nM of dopamine, noradrenaline or adrenaline, did not affect EFS-induced contractions. In tetrodotoxin (1mM) pre-treated (30 min) RIEVD, pre-incubation with 6-ND (0.1nM) did not caused leftward shifts in the concentration-dependent contractions induced by noradrenaline, adrenaline, or dopamine. Pre-incubation of the RIEVD with the α 2A -adrenoceptor antagonist idazoxan (30 min, 10 nM) did not affect dopamine, noradrenaline, adrenaline, and EFS-induced contractions. However, when idazoxan (10nM) and 6-ND (0.1nM) were simultaneously pre-incubated (30 min), a signi cant potentiation of the EFS-induced contractions of the RIEVD was observed. 6nitrodopamine causes remarkable potentiation of dopamine, noradrenaline, and adrenaline contractions on the RIEVD, due to activation of adrenergic terminals, possibly via pre-synaptic adrenoceptors.

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Mechanisms of adaptive supersensitivity in vas deferens

Cited by 11 publications

References 96 publications

Neuroeffector apparatus in gastrointestinal smooth muscle organs

Neuroeffector apparatus in gastrointestinal smooth muscle organs

Purinergic signalling in the reproductive system in health and disease

6-Nitrodopamine potentiates contractions of rat isolated vas deferens induced by noradrenaline, adrenaline, dopamine and electric field stimulation

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