Mechanisms of angiogenesis in tumour

Zhang, Run; Yao, Yutong; Gao, Hanwei; Hu, Xin

doi:10.3389/fonc.2024.1359069

Cited by 8 publications

(1 citation statement)

References 188 publications

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“…EVs play a role in cancer progression by promoting tumor angiogenesis, the formation of new blood vessels from existing ones to nourish tumor cells, aiding in their survival, growth, and dissemination [ 48 ]. This complex process includes multiple cell types and intricate signaling pathways [ 49 ], encompassing two primary mechanisms: sprouting angiogenesis, where endothelial cells create buds in response to angiogenic signals, and intussusceptive angiogenesis, involving the penetration of existing vessels by mesenchymal tissues and the creation of transmural vascular columns [ 50 ].…”

Section: Involvement Of Evs In Cancer Pathogenesismentioning

confidence: 99%

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Lin,

Zhou,

Ding

et al. 2024

Eur J Med Res

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Cancer, a prevalent and complex disease, presents a significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion of nearby tissues, and spread to distant organs. Its progression involves a complex interplay of several elements and processes. Extracellular vesicles (EVs) serve as critical intermediaries in intercellular communication, transporting critical molecules such as lipids, RNA, membrane, and cytoplasmic proteins between cells. They significantly contribute to the progression, development, and dissemination of primary tumors by facilitating the exchange of information and transmitting signals that regulate tumor growth and metastasis. However, EVs do not have a singular impact on cancer; instead, they play a multifaceted dual role. Under specific circumstances, they can impede tumor growth and influence cancer by delivering oncogenic factors or triggering an immune response. Furthermore, EVs from different sources demonstrate distinct advantages in inhibiting cancer. This research examines the biological characteristics of EVs and their involvement in cancer development to establish a theoretical foundation for better understanding the connection between EVs and cancer. Here, we discuss the potential of EVs from various sources in cancer therapy, as well as the current status and future prospects of engineered EVs in developing more effective cancer treatments.

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Section: Involvement Of Evs In Cancer Pathogenesismentioning

confidence: 99%

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Lin,

Zhou,

Ding

et al. 2024

Eur J Med Res

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Causal associations of tea consumption on risk of pancreatic adenocarcinoma and the mediating role of vascular endothelial growth factor D levels

Ouyang,

Zhou,

Chu

et al. 2024

Br J Nutr

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Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). To examine the mediating effects, we explored the potential mechanisms by which tea intake reduces the risk of pancreatic adenocarcinoma. Based on the oral bioavailability and drug-like properties in Traditional Chinese Medicine Systems Pharmacology database, we selected the main active ingredients of tea. We screened out the fifteen representative targeted genes by Pharmmapper database, and the gene ontology enrichment analysis showed that these targeted genes were related to vascular endothelial growth factor (VEGF) pathway. The two-step MR analysis of results showed that only VEGF-D played a mediating role, with a mediation ratio of 0·230 (0·066, 0·394). In conclusion, the findings suggest that VEGF-D mediates the effect of tea intake on the risk of pancreatic adenocarcinoma.

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Chemerin in immunity

Laffranchi,

Schioppa,

Sozio

et al. 2024

Journal of Leukocyte Biology

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Chemerin is a distant member of the cystatin protein family, initially discovered as a chemotactic factor and subsequently also reported to act as adipokine and angiogenetic factor. The biological activity of chemerin is regulated at different levels, such as gene expression, protein processing, and interaction with both signaling and nonsignaling receptors. Chemerin is mostly produced by stromal cells, such as adipocytes, fibroblasts, and epithelial and endothelial cells, and circulates in almost all human tissues as a zymogen that needs to be proteolytically activated to exert its biological functions. At the receptor level, chemerin binds a G protein-coupled 7-transmembrane domain receptor Chemerin1 (also named ChemR23 and CMKLR1), mostly expressed by innate immune cells, such as macrophages, dendritic cells, and natural killer cells, and by border cells. In addition, chemerin may bind GPR1, a weak signaling receptor, and CCRL2, a nonsignaling receptor expressed by barrier cells, such as endothelial and epithelial cells, able to regulate leukocytes’ migration by multiple mechanisms. The aim of this review is to summarize the contribution of chemerin in the regulation of immune responses.

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Mechanisms of angiogenesis in tumour

Cited by 8 publications

References 188 publications

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Causal associations of tea consumption on risk of pancreatic adenocarcinoma and the mediating role of vascular endothelial growth factor D levels

Chemerin in immunity

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