Mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum diels (combretaceae): Involvement of opioidergic and (α1 and β)-adrenergic pathways

Ahmad, Mubarak Hussaini; Zezi, Abdulkadir Umar; Anafi, Sherifat Bola; Alhassan, Zakariyya; Mohammed, Mustapha; Danraka, Rabi’u Nuhu

doi:10.1016/j.jep.2020.113750

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…Therefore, the findings in the current study have shown that the LD 50 of the MECA orally could be more than 5000 mg/kg. Previous research reported by Ahmad et al (2020aAhmad et al ( , 2020b revealed that the oral LD 50 of Combretum hypopilinum was higher than 5000 mg/kg. In another study by Yerima et al (2014), the oral LD 50 of the Tamarindus indica bark was also greater than 5000 mg/kg.…”

Section: Discussionmentioning

confidence: 89%

Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Nock

Abraham

Ahmad

2022

JoBAZ

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Background Pain, inflammation and fever are serious conditions that are associated with various disease conditions. In modern medicine, non-steroidal anti-inflammatory drugs (NSAIDs), opioids together with corticosteroids have been considered to manage algesia and inflammation-related conditions. However, these conventional drugs are not affordable, not readily available, particularly to people living in rural areas in developing nations. Besides, they are associated with undesirable pharmacological actions. Generally, medicinal plants have been employed to manage various ailments. In Northern-Nigeria, the leaves of Culcasia angolensis (Araceae) are used traditionally to manage pain, fever and inflammation. However, scientific data validating its folkloric claim in treating pain and inflammatory-related abnormalities are not available. Hence, the current study aims to validate the antinociceptive, anti-inflammatory and antipyretic potentials of the methanol leaf extract of Culcasia angolensis (MECA). Phytochemical and acute toxicity effects of the MECA were conducted as per standard experimental procedures. The analgesic potential of the MECA was determined using abdominal writhing elicited by acetic acid and hot plate tests in mice. The actions of the MECA on acute inflammation were conducted using formalin-induced hind paw oedema and carrageenan-induced paw oedema. The Brewer's yeast-induced pyrexia was employed to check its antipyretic effect. Results The MECA inhibited abdominal writhes produced by acetic acid administration (p < 0.05) and elevated the pain threshold in the hot plate test. The MECA also reduced the formalin-induced paw oedema. Besides, it produced an effective (p < 0.05) and dose-dependent action against oedema produced by carrageenan and reduced the rectal temperature against the pyrexia caused by Brewer's yeast administration. Conclusions The outcome of the study suggests that the MECA could possess pharmacologically active constituents with antinociceptive, anti-inflammatory and antipyretic properties. Therefore, the results justified its ethnomedicinal use to manage pain and inflammatory-associated conditions.

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Section: Discussionmentioning

confidence: 89%

Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Nock

Abraham

Ahmad

2022

JoBAZ

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“…Normal saline was administered in group 1 at a dosage of 10 ml/kg while castor oil (0.1 ml/kg) was administered in group II as normal. The remaining classes, III, IV and V received the raw MECSL extract at 50, 150, and 300 mg/kg in an i.p pathway, respectively [12]. The suspension of charcoal (water) at a dosage of 0.2 ml was applied to each mouse after 15minutes of the abovementioned treatments.…”

Section: Gastrointestinal Tract (Git) Motility (Charcoal Meal Protocol)mentioning

confidence: 99%

Study The Pharmacological Activity Of Methanolic Extract Of Cercis Siliquastrum L. Leaves On Animal Model

2022

pnr

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Cercis siliquastrum (Judas tree) is a commonly used traditional medicine in Iraq with drug discovery potential. The aim of this study was to investigate the in vivo acutes toxicity, analgesic activity by acetic acid induced writhing model, Anti-inflammatory by Carrageenan induced paw edema method, gastrointestinal tract (GIT) motility by charcoal meal protocol, antidepressant activity by using forced swimming test (FST) model of methanolic extract Cercis siliquastrum L. leaves (MECSL). Differenet concentration of MECSL curde extract was used (50 mg/kg, 150 mg/kg, 300 mg/kg. The results revealed that Cercis siliquastrum methanloic extract is dose dependent. Crude MECSL extract proved a strong analgesic, anti-inflammatory, and properties.

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“…Approximately 75% of the global personalities use herbal preparations for their basic health needs (Muhammad et al, 2021). The biological screening of medicinal plants has motivated the discovery of noble and effective agents against various disorders (Ahmad et al, 2020). About one-third of the medicinal products used in modern medicine were obtained from medicinal plants (Usman et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Acacia sieberiana (Fabaceae) Attenuates Paracetamol and Bile Duct Ligation-Induced Hepatotoxicity via Modulation of Biochemical and Oxidative Stress Biomarkers

Watafua

Ejiofor

Musa

et al. 2022

Preprint

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Background The plant Acacia sieberiana (Fabaceae) is traditionally used to manage hepatitis. This research work aims to investigate the hepatoprotective effectiveness of root bark extract of Acacia sieberiana (ASE) against paracetamol (PCM) and bile duct ligation (BDL) induced hepatotoxicity. The phytochemical and median lethal dose (LD50) investigations were conducted. The rats were pretreated with the ASE (250, 750, 1,500 mg/kg) once daily via oral route for 7 consecutive days. On the 8th day, liver injury was initiated by PCM administration (2g/kg). Similarly, in the BDL induced liver injury, the animals were administered ASE (125, 250 and 380 mg/kg) intraperitoneally for 7 consecutive days. After 24 hours, blood samples and hepatic tissues were obtained for biochemical and histopathological investigations. Results Phytocomponents determination revealed glycosides, triterpenes, glycosides, saponins, tannins, flavonoids and alkaloids. The oral and intraperitoneal LD50 values of the ASE were >5,000 and 1,300 mg/kg, respectively. The ASE efficiently (p<0.05) decreased the alanine transaminase (ALT) and aspartate transaminase (AST) levels and elevated the albumin and total protein (TP) levels. The direct bilirubin effectively (p<0.05) decreased at 750 mg/kg. Besides, the extract efficiently elevated the glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in relation to the PCM hepatotoxic group. Also, the malondialdehyde (MDA) concentration was reduced by the ASE. Meanwhile, in the BDL induced liver injury, the ASE remarkably (p<0.05) declined the AST, ALP, bilirubin and MDA. Besides, there was effective (p<0.05) elevation in SOD, GPx and CAT in the ASE treated groups. The morphology of liver tissue was preserved at 125 and 250 mg/kg ASE groups from BDL-induced necrosis and vascular congestion. Conclusion The study shows that the ASE has hepatoprotective actions against liver damage by possible modulation of biochemical and oxidative stress biomarkers

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Mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum diels (combretaceae): Involvement of opioidergic and (α1 and β)-adrenergic pathways

Cited by 13 publications

References 34 publications

Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Study The Pharmacological Activity Of Methanolic Extract Of Cercis Siliquastrum L. Leaves On Animal Model

Acacia sieberiana (Fabaceae) Attenuates Paracetamol and Bile Duct Ligation-Induced Hepatotoxicity via Modulation of Biochemical and Oxidative Stress Biomarkers

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