Rice is one of the most important routes for arsenic to enter the human food chain and threatens more than half of the world’s population. In addition, arsenic-contaminated soils and waters increase the concentration of this element in various tissues of rice plants. Thus, direct or indirect—infecting livestock and poultry—increase diseases such as respiratory diseases, gastrointestinal tract, liver, and cardiovascular diseases, cancer, and ultimately death in the long term. Therefore, finding different ways to reduce the uptake and transfer of arsenic by rice would reduce the contamination of rice plants with this dangerous element and improve animal and human nutrition and ultimately disease and mortality. In this article, we aim to take a small step in improving sustainable life on earth by referring to the various methods that researchers have taken to reduce rice contamination by arsenic in recent years. Adding micronutrients and macronutrients as fertilizer for rice is one way to improve this plant’s growth and health. In this study, by examining two types of macronutrients and two types of micronutrients, their role in reducing arsenic toxicity and absorption was investigated. Therefore, both calcium and phosphorus were selected from the macronutrients, and selenium and silicon were selected from the micronutrients, whose roles in previous studies had been investigated .