Mechanisms of Biofilm Formation in Clinically Used Biomaterials

Aguilera-Correa, John Jairo; Esteban, Jaime; Romera-García, David

doi:10.21775/9781912530328.04

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“…More importantly, in very few studies was a biofilm utilized in the evaluation of antimicrobial activity of the cements[ 50 , 62 ]. This situation is unfortunate given universal acknowledgement that PJI is a form of biofilm-associated implant-related musculoskeletal infection[ 34 , 82 , 83 , 89 - 91 ]; specifically, there is a “race to the top” in which the released antibiotic is inefficacious if a biofilm forms on the surface of the implant before the released antimicrobial agent gets there[ 92 - 94 ].…”

Section: Critical Appraisal Of the Literaturementioning

confidence: 99%

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Lewis¹

2022

WJO

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Prosthetic joint infection (PJI) is the most serious complication following total joint arthroplasty, this being because it is associated with, among other things, high morbidity and low quality of life, is difficult to prevent, and is very challenging to treat/manage. The many shortcomings of antibiotic-loaded poly (methyl methacrylate) (PMMA) bone cement (ALBC) as an agent for preventing and treating/managing PJI are well-known. One is that microorganisms responsible for most PJI cases, such as methicillin-resistant S. aureus , have developed or are developing resistance to gentamicin sulfate, which is the antibiotic in the vast majority of approved ALBC brands. This has led to many research efforts to develop cements that do not contain gentamicin (or, for that matter, any antibiotic) but demonstrate excellent antimicrobial efficacy. There is a sizeable body of literature on these so-called “antibiotic-free antimicrobial” PMMA bone cements (AFAMBCs). The present work is a comprehensive and critical review of this body. In addition to summaries of key trends in results of characterization studies of AFAMBCs, the attractive features and shortcomings of the literature are highlighted. Shortcomings provide motivation for future work, with some ideas being formulation of a new generation of AFAMBCs by, example, adding a nanostructured material and/or an extract from a natural product to the powder and/or liquid of the basis cement, respectively.

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Section: Critical Appraisal Of the Literaturementioning

confidence: 99%

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Lewis¹

2022

WJO

View full text Add to dashboard Cite

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Mechanisms of Biofilm Formation in Clinically Used Biomaterials

Cited by 1 publication

References 0 publications

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

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