2017
DOI: 10.1002/cam4.1135
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Mechanisms of breast cancer risk in shift workers: association of telomere shortening with the duration and intensity of night work

Abstract: Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential me… Show more

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Cited by 41 publications
(51 citation statements)
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References 50 publications
(108 reference statements)
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“…This could be due to the influence of circadian rhythms on telomerase activity [55]; inflammation activity has been proven by Pavanello et al in two investigations [56,59]. Another evidence was done by Samulin Erdem and colleagues [57] that observed the telomere shortening correlated with the duration and intensity of SW and may be a contributing factor for breast cancer risk among the female workforce.…”
Section: Discussionmentioning
confidence: 89%
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“…This could be due to the influence of circadian rhythms on telomerase activity [55]; inflammation activity has been proven by Pavanello et al in two investigations [56,59]. Another evidence was done by Samulin Erdem and colleagues [57] that observed the telomere shortening correlated with the duration and intensity of SW and may be a contributing factor for breast cancer risk among the female workforce.…”
Section: Discussionmentioning
confidence: 89%
“…Telomere length was assessed from 563 breast cancer of shift workers and 619 controls. Erdem et al [57] demonstrate that telomere length is affected by intensive SW, as work with six successive nights for more than 5 years was correlated with decreased telomere lengths (−3.18, 95% CI: −6.46 to −0.58, p = 0.016). Telomere shortening is also correlated with a rise in breast cancer risk in workers with long periods of successive night shifts.…”
Section: Results Of Eligible Studiesmentioning
confidence: 99%
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