Mechanisms of Cancer Invasion and Metastases

Liotta, Lance A.

doi:10.1007/978-94-009-2528-1_7

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…Metastasis is not only a complex process but also the major cause of cancer-related deaths 14 . Previous studies have shown that the EMT process plays a critical role in regulating cancer metastasis 15–17 .…”

Section: Discussionmentioning

confidence: 99%

Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells

Zhu

Jing

et al. 2017

oncol res

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Ras-association domain family 6 (RASSF6), a member of the RASSF family, is frequently downregulated in various types of cancer. However, the roles of RASSF6 in human hepatocellular carcinoma (HCC) are still unclear. In this study, we investigated the biological functions and related molecular mechanisms in HCC. Our results found that RASSF6 is expressed in low amounts in HCC tissues and cell lines. Overexpression of RASSF6 obviously inhibited the proliferation, invasion, and EMT process in HCC cells. Furthermore, overexpression of RASFF6 greatly downregulated the protein levels of phosphorylated focal adhesion kinase (FAK), MMP-2, and MMP-9 in HepG2 cells. Last, overexpression of RASFF6 significantly attenuated tumor growth in Balb/c nude mice. In conclusion, the present study revealed that RASFF6 can inhibit the proliferation, invasion, and migration of HCC cells both in vivo and in vitro. These inhibitory effects are through suppressing FAK phosphorylation, leading to decreased MMP-2/9 expression. RASFF6 is therefore a potential therapeutic target for treating HCC.

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Section: Discussionmentioning

confidence: 99%

Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells

Zhu

Jing

et al. 2017

oncol res

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“…The plasminogen activator/plasmin system also plays a role in modification of the extracellular matrix. Two types of plasminogen activator (PA) have been identified in neoplastic tissue: a urokinase-like PA, which is secreted by most carcinomas, and a tissue activator type PA (62,71). The tissue activator type PA plays a major role in thrombolysis; as such it may participate in fibrin degradation at the primary tumor site and contribute to tumor cell release.…”

Section: Modification Of the Extracellular Matrixmentioning

confidence: 99%

Basement membrane antigens in preneoplastic and neoplastic conditions

Visser¹

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Mechanisms of Cancer Invasion and Metastases

Cited by 2 publications

References 59 publications

Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells

Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells

Basement membrane antigens in preneoplastic and neoplastic conditions

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