Mechanisms of carcinogenesis with particular reference to the oral mucosa

Boyd, Nicholas M.; Reade, Peter C.

doi:10.1111/j.1600-0714.1988.tb01524.x

Cited by 29 publications

(17 citation statements)

References 110 publications

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“…This has previously been reviewed (Boyd and Reade, 1988;Field, 1992;Scully, 1993), as has been the molecular virology of human oral cancer (Park et al, 1991;Steele and Shillitoe, 1991;Scully, 1993;Yeudall, 1992). This review focuses on the current status of the molecular biology of human oral cancer.…”

Section: Crit Rev Oral Biol Medmentioning

confidence: 99%

Molecular Biology of Human Oral Cancer

Wong

Todd

Tsuji

et al. 1996

Critical Reviews in Oral Biology & Medicine

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ABSTRACT:The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of human cancers, our understanding of human oral cancer lags behind that of cancer of other body sites. This review attempts to assess the current status of the molecular biology of human oral cancer.

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Section: Crit Rev Oral Biol Medmentioning

confidence: 99%

Molecular Biology of Human Oral Cancer

Wong

Todd

Tsuji

et al. 1996

Critical Reviews in Oral Biology & Medicine

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“…These epoxides are absorbed into the systemic circulation when smoked and subsequently destroyed by epoxide hydratase. Nevertheless, failure of this enzyme to detoxify the carcinogens leads to the formation of electrophiles which possess an uncharged or positively charged electron-deficient atom that can result in the formation of covalent bonds with DNA characterizing early phases of carcinogenesis (Boyd and Read 1988). In this sense, the balance between tobacco products detoxification is considered to be crucial in determining the carcinogenicity (Venkateswara Rao et al 1997).…”

Section: Resultsmentioning

confidence: 98%

Expression of placental glutathione S-transferase in rat tongue mucosa exposed to cigarette smoke

Ribeiro

Assis²

2007

J Mol Hist

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Glutatione S-transferases (GSTs) are a family of enzymes involved in detoxification of xenobiotics. Placental GST, known as GST-P, has been detected in tissues following exposure to carcinogenic agents being regarded a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. The aim of this study was to investigate the expressivity of GST-P positive foci in the rat tongue mucosa exposed to cigarette smoke by means of immunohistochemistry. A total of twelve male Wistar rats were distributed into two groups: negative control and experimental group exposed to cigarette smoke during 75 days. After experimental period, no histopathological changes in the tongue mucosa were evidenced in the negative control and the experimental group. However, a total of five GST-P positive foci were detected in two out of six animals exposed to cigarrette smoke. None control animals were noticed GST-P positive foci. These data indicate that expression of GST-P may reflect the carcinogenic effect of cigarette smoke as well as the genetic susceptibility of animals in relation to continuous carcinogens exposure.

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“…Cancer is a multifactorial genetic disease whose development involves a multitude of genes (1). Microarray analyses have identified thousands of genes that are DESCRIPTION OF over-or underexpressed in specific tumor samples.…”

Section: Introductionmentioning

confidence: 99%

“…β-Adrenergic receptors are divided into β 1 , β 2 , and β 3 subtypes (8). They belong to the superfam-β-Adrenergic receptors transduce signals from catecholamines to the G protein, which, through a cascade ily of G-protein-coupled receptors (GPCRs) and are characterized by forming a pocket containing binding of chemical reactions, generates highly specific parallel signals with neuroendocrine functions in cells (1).…”

Section: Introductionmentioning

confidence: 99%

β-Adrenergic Receptors in Cancer: Therapeutic Implications

Pérez‐Sayáns

Martín²,

Barros³

et al. 2010

oncol res

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The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship of ADRB2 with various aspects related to cancer. Basically, it seems to be related with cell proliferation and apoptosis, chemotaxis, development of metastasis and tumor growth, and angiogenesis. The purpose of this review is to update the implications of these receptors in the pathogenesis of cancer and study the possible application of agonist drugs and/or antagonists in antitumor therapy.

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Mechanisms of carcinogenesis with particular reference to the oral mucosa

Abstract: Three types of stimulus, chemical, physical and viral, are known to be carcinogenic to susceptible animals. This review considers these stimuli and their possible mechanisms in general terms and their possible relevance to the induction of oral mucosal carcinoma in particular.

Cited by 29 publications

References 110 publications

Molecular Biology of Human Oral Cancer

Molecular Biology of Human Oral Cancer

Expression of placental glutathione S-transferase in rat tongue mucosa exposed to cigarette smoke

β-Adrenergic Receptors in Cancer: Therapeutic Implications

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