Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

Chen, Linjie; Chen, Changyou; Wang, Pingping; Song, Tao

doi:10.1155/2017/1564634

Cited by 35 publications

(28 citation statements)

References 124 publications

(159 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of MNPs internalized by cells, the chances to get in contact with cell organelles are increased, resulting in a high efficiency of the MHT treatment even when low MNPs concentrations are used. In this respect, Chen et al 31 included in their excellent review several reports about targeted magnetic hyperthermia showing that if MNPs are combined with or incorporate into tumor cells, a high impact on the cellular viability without a perceptible macroscopic temperature rise can be achieved. Also, Marcos-Campos et al showed that the selective cytotoxicity of MNPs under an AMF could be the result of the local damage produced by MNPs.…”

Section: Mechanisms For Different Wht and Mht Cytotoxic Effectsmentioning

confidence: 99%

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Herea¹,

Danceanu²,

Radu³

et al. 2018

IJN

View full text Add to dashboard Cite

IntroductionHyperthermia (HT) based on magnetic nanoparticles (MNPs) represents a promising approach to induce the apoptosis/necrosis of tumor cells through the heat generated by MNPs submitted to alternating magnetic fields. However, the effects of temperature distribution on the cancer cells’ viability as well as heat resistance of various tumor cell types warrant further investigation.MethodsIn this work, the effects induced by magnetic hyperthermia (MHT) and conventional water-based hyperthermia (WHT) on the viability of human osteosarcoma cells at different temperatures (37°C–47°C) was comparatively investigated. Fe-Cr-Nb-B magnetic nanoparticles were submitted either to alternating magnetic fields or to infrared radiation generated by a water-heated incubator.ResultsIn terms of cell viability, significant differences could be observed after applying the two HT treatment methods. At about equal equilibrium temperatures, MHT was on average 16% more efficient in inducing cytotoxicity effects compared to WHT, as assessed by MTT cytotoxicity assay.ConclusionWe propose the phenomena can be explained by the significantly higher cytotoxic effects initiated during MHT treatment in the vicinity of the heat-generating MNPs compared to the effects triggered by the homogeneously distributed temperature during WHT. These in vitro results confirm other previous findings regarding the superior efficiency of MHT over WHT and explain the cytotoxicity differences observed between the two antitumor HT methods.

show abstract

Section: Mechanisms For Different Wht and Mht Cytotoxic Effectsmentioning

confidence: 99%

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Herea¹,

Danceanu²,

Radu³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Importantly, this has implications for IONP design and whether efforts to improve the internalisation of these nanoparticles through functionalisation with targeting agents are necessary. Nonetheless, further studies are needed to elucidate whether intracellular nanoparticles can contribute to treatment efficacy in alternative ways such as instigating anti-tumour immune responses or disrupting intracellular signalling pathways that may enhance the effects of combination therapies, as magnetic hyperthermia has been reported to do [44,45].…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

et al. 2020

View full text Add to dashboard Cite

Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials in various solid malignancies and subsequently achieved clinical approval to treat glioblastoma and prostate cancer in 2011 and 2018, respectively. However, despite recent clinical advances, many questions remain with regard to the underlying mechanisms involved in this therapy. One such query is whether intracellular or extracellular nanoparticles are necessary for treatment efficacy. Herein, we compare the effects of intracellular and extracellular magnetic hyperthermia in BxPC-3 cells to determine the differences in efficacy between both. Extracellular magnetic hyperthermia at temperatures between 40–42.5 °C could induce significant levels of necrosis in these cells, whereas intracellular magnetic hyperthermia resulted in no change in viability. This led to a discussion on the overall relevance of intracellular nanoparticles to the efficacy of magnetic hyperthermia therapy.

show abstract

“…Reactive oxygen species are resulted to make the apoptosis of osteoclast. 28 With a reduction of osteoclast cell number, this nanoparticle gives authority to osteocytes to make new bone tissue. This makes the magnetic nanoparticle has a therapeutic role.…”

Section: Magnetic Nanoparticle As Osteoporosis Therapymentioning

confidence: 99%

The Potential of Soy Isoflavones (Glycine max) and Magnetic Hydroxyapatite Nanoparticles as Osteoporosis Therapy for Menopausal Women

Jannah

Ebnudesita

Dienanta

et al. 2020

IABJ

View full text Add to dashboard Cite

Background: Menopausal women experience amenorrhea for 12 consecutive months. In Indonesia, one of four women aged 50 – 80 years has a risk of osteoporosis. This age range is related to the menopause phase. Low estrogen levels in menopausal women cause decreased bone mineral density resulting in osteoporosis. Osteoporosis is a degenerative disease characterized by decreased bone density and bone strength that causes fractures. This literature review aims to determine the potential of soy isoflavones (Glycine max) and magnetic hydroxyapatite nanoparticles as alternative therapies for osteoporosis in menopausal women. Reviews: Soy isoflavones are phytoestrogens because they have estrogen-like structures and functions. Some studies explain that phytoestrogens have benefits in osteoporosis therapy by maintaining bone density through decreasing osteoclast resorption and stimulating osteoblasts. Consuming enough soy supplements everyday has been shown to increase bone mineral density. This effect is strengthened by coating the soy isoflavones with magnetic hydroxyapatite nanoparticles through two mechanisms, as a therapeutic agent and drug carrier. The magnetic field of the magnetic nanoparticles produces force and torque to increase the temperature until 42°C and trigger organelles movement, causing apoptosis of osteoclasts. Hydroxyapatite is a major component of bone mineral that replaces bone tissue deformity and has an osteoblastic effect in bone regeneration. Nano-sized hydroxyapatite will increase material properties and stability in high temperatures. However, hydroxyapatite has less magnetic activity so this function is completed by magnetic nanoparticles. Summary: Therefore, the combination of soy isoflavones and magnetic hydroxyapatite nanoparticles works synergistically as an alternative therapy for osteoporosis in menopausal women.

show abstract

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

Cited by 35 publications

References 124 publications

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

The Potential of Soy Isoflavones (Glycine max) and Magnetic Hydroxyapatite Nanoparticles as Osteoporosis Therapy for Menopausal Women

Contact Info

Product

Resources

About