Mechanisms of compensation and decompensation in dilated cardiomyopathy

Hirota, Yuzo; Shimizu, Gen; Kaku, Kiyotaka; Saito, Takaharu; Kino, Masaya; Kawamura, Keishiro

doi:10.1016/s0002-9149(84)80140-x

Cited by 32 publications

(3 citation statements)

References 21 publications

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“…These compensatory mechanisms are associated with heart remodeling which finally becomes detrimental and irreversible in the long-term. A cellular hypertrophy is observed which partially compensates the loss of cardiomyocytes [ 11 ] (See Table 1 ). When the first symptoms occur, the major structural modification is the enlargement of the left ventricle, up to around 140% its initial size [ 12 ].…”

Section: Anatomical and Cellular Features Of Dilated Cardiomyopathymentioning

confidence: 99%

3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

Camman

Joanne

Agbulut

et al. 2022

Bioactive Materials

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The pathophysiology of dilated cardiomyopathy (DCM), one major cause of heart failure, is characterized by the dilation of the heart but remains poorly understood because of the lack of adequate in vitro models. Current 2D models do not allow for the 3D organotypic organization of cardiomyocytes and do not reproduce the ECM perturbations. In this review, the different strategies to mimic the chemical, physical and topographical properties of the cardiac tissue affected by DCM are presented. The advantages and drawbacks of techniques generating anisotropy required for the cardiomyocytes alignment are discussed. In addition, the different methods creating macroporosity and favoring organotypic organization are compared. Besides, the advances in the induced pluripotent stem cells technology to generate cardiac cells from healthy or DCM patients will be described. Thanks to the biomaterial design, some features of the DCM extracellular matrix such as stiffness, porosity, topography or chemical changes can impact the cardiomyocytes function in vitro and increase their maturation. By mimicking the affected heart, both at the cellular and at the tissue level, 3D models will enable a better understanding of the pathology and favor the discovery of novel therapies.

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Section: Anatomical and Cellular Features Of Dilated Cardiomyopathymentioning

confidence: 99%

3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

Camman

Joanne

Agbulut

et al. 2022

Bioactive Materials

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“…4 Decreased myocardial contractility is the prime mechanical disorder. 5 The histopathological findings, such as myocyte hypertrophy, degeneration, interstitial fibrosis, and endocardial proliferative changes, are in themselves non-specific. 69 The major contribution of an endomyocardial biopsy specimen, therefore, is to rule out other conditions that can cause congestive heart failure, such as idiopathic myocarditis.10 The existence of a relation between the features of endomyocardial biopsy specimens and prognosis is also controversial.…”

mentioning

confidence: 99%

“…69 The major contribution of an endomyocardial biopsy specimen, therefore, is to rule out other conditions that can cause congestive heart failure, such as idiopathic myocarditis.10 The existence of a relation between the features of endomyocardial biopsy specimens and prognosis is also controversial. Some workers found that prognosis was poor when myocardial fibrosis was widespread,7 1 but others did not find such a clear correlation *Present address: Department of Paediatrics, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori-Ken, 036 Japan.…”

mentioning

confidence: 99%

Dilated cardiomyopathy: diagnostic accuracy of endomyocardial biopsy.

Yonesaka¹,

Becker²

1987

Heart

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SUMMARY A histopathological index of contractility failure, which was reported to be accurate for the diagnosis of idiopathic dilated or congestive cardiomyopathy in Japan, was used to assess endomyocardial biopsy specimens from 41 Dutch patients with suspected dilated cardiomyopathy. The calculated index had a sensitivity of 62 5% and a specificity of 68% for idiopathic dilated or congestive cardiomyopathy. These disappointing results indicate that the histopathological index of contractility failure does not reliably distinguish between idiopathic dilated cardiomyopathy and other diseases that cause congestive heart failure.

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Echocardiographic findings of left ventricular hypertrophy and normalization of parameters of left ventricular function in patients with previous evidence of dilated and poorly contracting left ventricle and coexisting systemic hypertension

Dall'Aglio¹,

Nicolosi²,

Burelli³

et al. 1989

Clinical Cardiology

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Summary:We report 6 cases of dilated left ventricle with poor left ventricular function and coexisting systemic hypertension in whom left ventricular hypertrophy and normalization of left ventricular function and dimensions have been subsequently documented by M-mode and twodimensional echocardiographic follow-up studies. Four patients were in New York Heart Association functional Class IV, one in Class 111, and one in Class I1 when first seen. Normalization of left ventricular function and dimensions and features of left ventricular hypertrophy (fractional shortening from 15.0f5.2 to 39.7i-5.4, left ventricular end-diastolic diameter from 6.6k0.6 to 4.6f0.6 cm, left ventricular end-systolic diameter from 5.6f0.8 to 2.8 k 0 . 6 cm, left ventricular end-diastolic radius/posterior wall thickness from 3.1 f0.5 to 2.0f0.4, interventricular septum thickness from 1.2f0.3 to 1.5f0.3 cm, left atrium from 4.6f0.6 to 3.5k0.9 cm) were achieved after adequate medical treatment at the end of the follow-up (11-39 months). It appears from this study that normalization of left ventricular dimensions and function with features of left ventricular hypertrophy can occur after adequate treatment in patients with echocardiographic findings of dilated and poorly contracting left ventricle and coexisting systemic hypertension. It is conceivable, in such cases, to classify the dilatation of the left ventricle as secondary and to suggest the hypothesis

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Mechanisms of compensation and decompensation in dilated cardiomyopathy

Cited by 32 publications

References 21 publications

3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

Dilated cardiomyopathy: diagnostic accuracy of endomyocardial biopsy.

Echocardiographic findings of left ventricular hypertrophy and normalization of parameters of left ventricular function in patients with previous evidence of dilated and poorly contracting left ventricle and coexisting systemic hypertension

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