Mechanisms of drug release from cyclodextrin complexes

Stella, Valentino J.; Rao, Venkatramana M.; Zannou, Erika A.; Zia, V.

doi:10.1016/s0169-409x(98)00052-0

Cited by 371 publications

(188 citation statements)

References 48 publications

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“…[3][4][5][6][7] This capability has been of assistance for different applications in food technology, pharmaceutical, and chemical industriesaswellasinagricultureandenvironmentalengineering. [8][9][10][11] Generally, the thermodynamic stability of inclusion compounds depends on three facts: the size of host and guest molecules (normally, the highest association constants are being found for host-guest complexes that fit in a tight way 5 ), the dehydration of host molecules, and the removal of water molecules from the cyclodextrin cavity. Consequently, complex formation involving γ-cyclodextrin is not a favorable process because it has a large cavity volume (510 Å 3 ) when compared with those for R-and -cyclodextrin [(176 and 346) Å 3 , respectively].…”

Section: Introductionmentioning

confidence: 99%

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

et al. 2008

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Values of binary mutual diffusion (interdiffusion) coefficients, obtained by using the Taylor dispersion method, for aqueous solutions of γ-cyclodextrin in the concentration range from (0.002 to 0.010) mol · dm -3 and temperatures (298.15 and 310.15) K are reported. From these experimental results, the hydrodynamic radius values for the γ-cyclodextrin are estimated. Also, the measured diffusion coefficients are used with both Hartley's and Gordon's equations to estimate activity coefficients for aqueous γ-cyclodextrin. These studies are complemented by some density and viscosity measurements, carried out at the same range of concentrations and temperatures. The effect of both the viscosity of the medium and the formation of γ-cyclodextrin dimers on the estimated hydrodynamic radius is discussed.

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Section: Introductionmentioning

confidence: 99%

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

et al. 2008

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“…The Drug-CD complex exhibit good aqueous solubility which is different from that of the free drug. This is because of changes in many of the physicochemical properties of drug without alteration of the intrinsic pharmacokinetic 32,33 .…”

Section: Resultsmentioning

confidence: 99%

EVALUATION OF SOLUBILITY OF SIMVASTATIN USING Β-Cyclodextrin BY SOLID DISPERSION TECHNIQUE

Punitha

Kl²

2011

Int Jour of Biomed Res

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Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-β cyclodextrin dispersions were prepared with a view to study the influence of β-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of β-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when β-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of drug and carrier.

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“…Cyclodextrins complexes with penetration enhancers have the additive effect on the permeability of drug the membrane barriers. [26,[92][93][94][95][96][97] Loftsson et al studied the permeability study of testosterone through transdermal delivery from o/w cream through hairless mouse skin using 2-hydroxypropyl-β-cyclodextrin and glycerol mono ether, a penetration enhancer. HP-β-CD showed about 60% increase in testosterone flux whereas extract showed only 40% increase when added to the cream.…”

Section: Permeability Enhancementmentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

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Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

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Mechanisms of drug release from cyclodextrin complexes

Cited by 371 publications

References 48 publications

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

EVALUATION OF SOLUBILITY OF SIMVASTATIN USING Β-Cyclodextrin BY SOLID DISPERSION TECHNIQUE

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