2017
DOI: 10.3390/vaccines5040042
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Mechanisms of Entry and Endosomal Pathway of African Swine Fever Virus

Abstract: African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and presently spreading in Russia and neighboring countries, including Poland and recently, the Czech Republic. This uncontrolled dissemination is a world-wide threat, as no specific protection or vaccine is available. ASFV is a very complex icosahedral, enveloped virus about 200 nm in diameter, which infects several members of pigs. The virus enters host cells by receptor-mediated endocytosis that depends on… Show more

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Cited by 57 publications
(51 citation statements)
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References 61 publications
(113 reference statements)
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“…Since rabankyrin 5 protein (effector of Rab5) is associated with macropinosomes it could be considered a molecular marker for macropinocytosis. Furthermore Pak1 is activated by the small GTPase Rac1 (Ras-related C3 botulinum toxin substrate) and is related to macropinocytosis of Ad3, vaccinia virus and T. cruzi (Al Soraj et al, 2012 ; Barrias et al, 2013 ; Sánchez et al, 2017 ). To check if macropinocytosis can be a path for T. gondii entry into host cells, we used anti-rabankyrin 5 and anti-Pak1 antibodies to label areas described as macropinosomes.…”
Section: Resultsmentioning
confidence: 99%
“…Since rabankyrin 5 protein (effector of Rab5) is associated with macropinosomes it could be considered a molecular marker for macropinocytosis. Furthermore Pak1 is activated by the small GTPase Rac1 (Ras-related C3 botulinum toxin substrate) and is related to macropinocytosis of Ad3, vaccinia virus and T. cruzi (Al Soraj et al, 2012 ; Barrias et al, 2013 ; Sánchez et al, 2017 ). To check if macropinocytosis can be a path for T. gondii entry into host cells, we used anti-rabankyrin 5 and anti-Pak1 antibodies to label areas described as macropinosomes.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, coronavirus mouse hepatitis virus (MHV) infection is inhibited when early endosome-associated proteins, RAB5 and EEA1, are down-regulated by siRNA (Burkard et al, 2014) and infectious bronchitis virus (IBV) release of the nucleocapsid into the cytoplasm (Wang et al, 2018) occurs through the fusion with endosome-lysosome membranes. These data suggest that coronaviruses exploit the early and late endosome compartment after viral entry, as several other viruses (adenovirus, human papillomavirus, polyomavirus, African swine fever virus, and influenza virus) (Lakadamyali et al, 2004;Sánchez et al, 2017;Spriggs et al, 2019).…”
Section: Lipid Rafts and Autophagy: Focus On Coronavirusmentioning
confidence: 89%
“…Several modes of cell entry for ASFV have been demonstrated (86,(94)(95)(96). Early studies on ASFV entry indicate receptordependent mechanisms including low pH and temperaturedependent events, and determined that ASFV binding to cell surfaces was saturable (97)(98)(99)(100).…”
Section: Asfv Entry and Early Events In The Infectious Cyclementioning
confidence: 99%
“…ASFV apparently also utilizes macropinocytosis, demonstrated by the use of chemical inhibitors, purified labeled virions, and fluorescent and transmission electron microscopy to monitor early events of ASFV infection in swine macrophages (94,116). The current working model for ASFV entry includes both clathrin-mediated endocytosis and macropinocytosis (86,95,96). Actin modulation through phosphoinositide-3-kinase (PI3K), Rac-1 Rho-GTPase and Pak-1 kinase signaling is important for ASFV internalization via macropinocytosis (85,94,96,118).…”
Section: Asfv Entry and Early Events In The Infectious Cyclementioning
confidence: 99%
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