Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer

Young, M. Rita I.; Wright, M. A.; Lozano, Yvonne; Matthews, Janice R.; Benefield, Janet; Prechel, Margaret

doi:10.1002/(sici)1097-0215(19960729)67:3<333::aid-ijc5>3.3.co;2-r

Cited by 36 publications

(49 citation statements)

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“…Of note was the absence of a significant increase in plasma levels of active TGF-␤. This was a surprise because we had previously reported that HNSCC secrete TGF-␤ [16,20]. Also, others had demonstrated increased levels of TGF-␤ in patients with other malignancies, such as colorectal or prostate cancer [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck

2003

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Section: Discussionmentioning

confidence: 99%

Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck

2003

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“…Phenotypically, TIL look like activated T cells, but these cells are functionally compromised [12]. In situ immunostaining with antibodies specific for T cell receptor (TcR)-associated signaling molecules as well as functional assays with TIL isolated from the tumor bed identified the following defects in these cells: absent or low expression of the ζ chain, which is the key signaling molecule in the TcR pathway [12,13]; decreased proliferation in response to mitogens or IL-2 [11,12]; inability to kill tumor cell targets [11]; imbalance in the cytokine profile, with the striking absence of IL-2 or IFN-γ production [14]; and evidence for DNA fragmentation in a considerable proportion of infiltrating T cells [12]. More recent studies confirm and extend these findings, as summarized in Table 2.…”

Section: Strategies Of Tumor Escapementioning

confidence: 99%

Immunobiology of head and neck cancer

Whiteside

2005

Cancer Metastasis Rev

146

122

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The development of head and neck cancer (HNC) is strongly influenced by the host immune system. Recent evidence for the presence of functional defects and for apoptosis of tumor-infiltrating as well as circulating T cells in patients with HNC emphasizes the fact that their antitumor responses are compromised. It appears that H&N tumors not only effectively escape from the host immune system but also actively corrupt the host antitumor response via several distinct mechanisms. Strategies for restoring immune competence of patients with HNC and for preventing tumor escape are necessary for more effective control of tumor progression. New immunotherapeutic approaches include cytokine-based and DC-based vaccines which are aimed at the restoration of tumor-specific responses and at the protection of immune cells from tumor-induced apoptosis.

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“…Not only do HNSCC tumors evade the immune system, they actively suppress anti-tumor immune responses through production of immune suppressive soluble factors and induction of immune inhibitory cells. The production of immune suppressive soluble factors, including TGF-b [53,54], prostaglandins [55], and FasL [56], actively suppresses anti-tumor effector mechanisms. The presence of immune inhibitory cells, including CD34 + progenitor cells, inhibitory macrophages, and T-regulatory cells, within the tumor and peripheral blood of HNSCC patients contribute to continued tumor survival and metastases by actively inhibiting T-cell anti-tumor effector mechanisms [4,57].…”

Section: Immunological Contributions To Mechanisms Of Tumor Growth Anmentioning

confidence: 99%

Mechanisms of Tumor Growth and Metastasis in Head and Neck Squamous Cell Carcinoma

Walsh

Lathers

Angela

et al. 2007

Curr. Treat. Options in Oncol.

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The formation and progression of head and neck squamous cell carcinoma (HNSCC) is multisystemic and involves the immune system, vascularization, and dissemination. Immune involvement includes the subversion of anti-tumor defenses. Vascularization involves both angiogenesis and vasculogenesis. Dissemination involves local tumor invasion as well as distant metastasis through processes including angiogenesis and lymphangiogenesis. Current studies in the dysregulation of various processes, including genetic stability, angiogenesis, lymphangiogenesis, immune regulation, and immune function, are opening opportunities for the development of targeted tumor therapies. The interrelationship of these processes in HNSCC development will be explored in this review.

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Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer

Cited by 36 publications

References 0 publications

Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck

Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck

Immunobiology of head and neck cancer

Mechanisms of Tumor Growth and Metastasis in Head and Neck Squamous Cell Carcinoma

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