Mechanisms of Improved Exercise Performance under Hyperoxia: On Haldane, Geppert, Zunz, and Eschenbacher Transformations

Ulrich, Silvia; Hasler, Elisabeth; Furian, Michael; Saxer, Stéphanie; Bloch, Konrad E.

doi:10.1159/000475536

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of oxygen during exercise training in patients with CTEPH and also PAH has been shown to improve exercise performance even in the absence of resting hypoxemia (hyperoxic exercise training) 12 . The mechanism of this benefit is felt to reflect improved arterial, muscular and cerebral oxygenation and reduced sympathetic tone 13 . Our finding that oxygen results in acute decline in PVR in some patients with CTEPH suggests potential for additional studies further examining use of oxygen therapy in CTEPH, including exploration of use of oxygen during exercise training sessions in CTEPH.…”

Section: Discussionmentioning

confidence: 99%

“…12 The mechanism of this benefit is felt to reflect improved arterial, muscular and cerebral oxygenation and reduced sympathetic tone. 13 Our finding that oxygen results in acute decline in PVR in some patients with CTEPH suggests potential for additional studies further examining use of oxygen therapy in CTEPH, including exploration of use of oxygen during exercise training sessions in CTEPH.…”

Section: Acute Response To 100% Oxygenmentioning

confidence: 99%

See 1 more Smart Citation

Acute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study

et al. 2023

View full text Add to dashboard Cite

Chronic thromboembolic pulmonary hypertension (CTEPH) is believed to involve both vascular obstruction and vasoconstriction; hence, pulmonary vasodilators such as riociguat may be beneficial. Acute vasoreactivity testing (AVT) is seldom performed routinely in CTEPH patients, so there is limited understanding of the frequency and significance of an acute vasodilator response. Systematic vasodilator testing with oxygen (O 2 ) and oxygen plus inhaled nitric oxide (O 2 + iNO) was performed as part of the Pulmonary Vascular Disease Omics (PVDOMICS) NHLBI project, providing an opportunity to examine AVT responses in CTEPH. Patients with CTEPH enrolled in PVDOMICS (n = 49, 40 with prevalent CTEPH [82%]) underwent right heart catheterization including AVT with O 2 and O 2 + iNO. Hemodynamics were obtained at baseline and with each challenge. Fourteen of 49 patients (29%) had >20% drop in pulmonary vascular resistance (PVR) with O 2 . With O 2 + iNO, 30/ 49 (61%) had >20% drop in PVR, 20% had >20% drop in mean pulmonary artery

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Acute Response To 100% Oxygenmentioning

confidence: 99%

Acute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…e slow recovery of the heart rate decline depends in part on the exercise load [12]. Judy believe that, although the direct measurement of VO2max is a golden method, however, due to problems and disputes in various aspects, for epidemiological studies of large samples, the submaximal program infers that the maximum oxygen uptake has been sufficiently effective and reliable [13].…”

Section: Literature Reviewmentioning

confidence: 99%

Maximal Oxygen Uptake in Breathing Exercises and Heart Rate Exercises Based on In-Depth Regression Equations

Min

2022

Advances in Multimedia

View full text Add to dashboard Cite

For the purpose of research, the maximum oxygen uptake of exercise training breathing and heart rate constructed based on the deep learning regression equation learn about the effects of training breathing and heart rate on VO2 max. Based on 77 healthy adults without chronic diseases (37 men and 40 women, aged 20–39 years old), who participate in two exercise tests (the first time is a direct test and the second time is a secondary quantitative load plan), in order to establish a second-level quantitative load scheme for power vehicles, the predictive equation for predicting the maximum oxygen uptake. The author researched and established a stable heart rate HRH based on gender, BMI, and second-level load; the second-level load RPE and R P E 1 are independent variables, the absolute value of the subject’s maximum oxygen uptake is the regression equation of the dependent variable. The experimental results prove that the reliability and validity of the second-level quantitative load scheme for power vehicles are better and can be used as the maximum oxygen uptake in the laboratory, directly tested with alternative submaximal solutions, and used for large-scale investigation of maximum oxygen uptake data. At the same time, since the load is submaximal, it can also be used to clinically assess the patient’s cardiorespiratory endurance.

show abstract

Symposium review: high altitude travel with pulmonary vascular disease

Titz,

Schneider,

Mueller

et al. 2024

The Journal of Physiology

View full text Add to dashboard Cite

Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are the main precapillary forms of pulmonary hypertension (PH) summarized as pulmonary vascular diseases (PVD). PVDs are characterized by exertional dyspnoea and oxygen desaturation, and reduced quality of life and survival. Medical therapies improve life expectancy and physical performance of PVD patients, of whom many wish to participate in professional work and recreational activities including traveling to high altitude. The exposure to the hypobaric hypoxic environment of mountain regions incurs the risk of high altitude adverse events (AEHA) due to severe hypoxaemia exacerbating symptoms and further increase in pulmonary artery pressure, which may lead to right heart decompensation. Recent prospective and randomized trials show that altitude‐induced hypoxaemia, pulmonary haemodynamic changes and impairment of exercise performance in PVD patients are in the range found in healthy people. The vast majority of optimally treated stable PVD patients who do not require long‐term oxygen therapy at low altitude can tolerate short‐term exposure to moderate altitudes up to 2500 m. PVD patients that reveal persistent severe resting hypoxaemia ( <80% for >30 min) at 2500 m respond well to supplemental oxygen therapy. Although there are no accurate predictors for AEHA, PVD patients with unfavourable risk profiles at low altitude, such as higher WHO functional class, lower exercise capacity with more pronounced exercise‐induced desaturation and more severely impaired haemodynamics, are at increased risk of AEHA. Therefore, doctors with experience in PVD and high‐altitude medicine should counsel PVD patients before any high‐altitude sojourn. This review aims to summarize recent literature and clinical recommendations about PVD patients travelling to high altitude. image

show abstract

Mechanisms of Improved Exercise Performance under Hyperoxia: On Haldane, Geppert, Zunz, and Eschenbacher Transformations

Cited by 4 publications

References 8 publications

Acute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study

Acute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study

Maximal Oxygen Uptake in Breathing Exercises and Heart Rate Exercises Based on In-Depth Regression Equations

Symposium review: high altitude travel with pulmonary vascular disease

Contact Info

Product

Resources

About