Mechanisms of Inhibin Signal Transduction

Bernard, Daniel J.; Chapman, Stacey C.; Woodruff, Teresa K.

doi:10.1210/rp.56.1.417

Cited by 86 publications

(47 citation statements)

References 125 publications

(218 reference statements)

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“…If the deficiency in FSH limited follicular development, then the ovaries from both groups of females should respond similarly to PMSG. FSH stimulates the production of gonadal inhibins which, in turn, feedback to the pituitary to inhibit FSH synthesis and secretion (Woodruff et al 1996, Bernard et al 2001. Because serum FSH levels are higher in LD than in SD hamsters as shown in the companion paper (Kenny et al 2002), we hypothesized that inhibin may be differentially regulated in different photoperiods.…”

Section: Discussionmentioning

confidence: 98%

Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin

Kenny

Bernard²,

Horton

et al. 2002

Journal of Endocrinology

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Inhibin production differs in ovaries of Siberian hamsters (Phodopus sungorus) exposed to long days (LD) or short days (SD). We believe that seasonal differences in serum follicle-stimulating hormone contribute to this difference. However, given the profound photoperiodic differences in follicle maturation, serum gonadotropins alone may not account for all of the observed differences in inhibin processing. To test this hypothesis, we challenged LD and SD female hamsters with exogenous gonadotropins. While both groups responded with increased inhibin expression, the effects were muted in ovaries of SD females and there was no evidence of ovulation in these animals. These data indicate that the ovaries of SD females are not immediately equipped to respond to gonadotropin stimulation. More generally, these data suggest that photoperiodic history affects ovarian inhibin production and secretion in response to gonadotropins.

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Section: Discussionmentioning

confidence: 98%

Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin

Kenny

Bernard²,

Horton

et al. 2002

Journal of Endocrinology

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“…The ligand-driven assembly of heteromeric receptor complex formation can occur in two steps, as seen with TGF␤ ligands, or in a single step, exemplified by BMP-receptor interactions (3). Activin A has high affinity for its type II receptors, ActRII and ActRIIB, but not for its type I receptor, ALK4 (ActRIB), despite the presence of a ligand-binding domain within ALK4 (5)(6)(7)(8). Following a two-step receptor complex formation, ALK4 contacts activin A that is already bound to ActRII/IIB (3,4) (Fig.…”

mentioning

confidence: 99%

Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

Zhu

Lin

Zou

et al. 2012

Journal of Biological Chemistry

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Background:The inhibin ␤-subunit interacts with activin type II receptor to antagonize activin signaling. Results: The inhibin ␣-subunit N terminus binds ALK4 to antagonize activin signaling. Conclusion: Inhibin ␣-subunit binding to ALK4 supports potent antagonism of constitutive activin-stimulated FSH production in pituitary cells. Significance: Understanding the mechanisms underlying control of pituitary FSH synthesis may provide treatment approaches to reproductive endocrine disorders.

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“…One major reason for this might be the fact that specific signaling receptors for inhibins have not yet been identified (60). Meanwhile it is known that inhibins are capable of binding type II activin receptors and BMP receptors through their ß-subunits, although with a very low affinity (60).…”

Section: Discussionmentioning

confidence: 99%

Inhibin-α subunit expression in uterine endometrioid adenocarcinomas and endometrial cancer cell lines: a potential prognostic factor

Mylonas

2011

Int J Mol Med

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Abstract. Inhibins/activins are secreted polypeptides of the transforming growth factor-ß superfamily, forming a family of dimeric, disulphide-linked proteins. Inhibins are composed of an ·-subunit and one of two possible ß-subunits. Both inhibins and activins have substantial roles in human reproduction and in endocrine-responsive tumors. However, the prognostic significance and clinical implications of the inhibin-· subunits in uterine endometrioid adenocarcinomas is still not clearly defined. A series of 231 uterine endometrioid adenocarcinomas of a previous well-characterized cohort were re-evaluated for the expression of the inhibin-· subunit and correlated with several clinicopathological characteristics and clinical outcome. Additionally, several endometrial epithelial cell lines (Ishikawa plus and minus, HEC-1A, HEC-1B and RL95-2) were analyzed for the expression of this subunit using immunohistochemical and molecular biological techniques. A significant association between the inhibin-· subunit and histological grade, surgical staging and myometrial invasion was demonstrated. Survival analysis demonstrated that inhibin-· immunoreactivity significantly affected progression-free, cause-specific and overall survival of patients with endometrioid adenocarcinomas. The analyzed endometrial cancer cell lines can also synthesize this subunit. Inhibin-· seems to have a substantial role in the carcinogenesis and pathology of uterine endometrioid carcinomas, and might be used as a marker to identify highrisk patients and may aid in the selection of patients for a more aggressive adjuvant therapy. Since uterine cancer cell lines express the inhibin-· subunit, they constitute adequate in vitro models for assessing its function in endometrial carcinogenesis. However, further research is warranted to elucidate the possible implications of inhibin-· in endometrial carcinogenesis.

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Mechanisms of Inhibin Signal Transduction

Cited by 86 publications

References 125 publications

Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin

Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin

Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

Inhibin-α subunit expression in uterine endometrioid adenocarcinomas and endometrial cancer cell lines: a potential prognostic factor

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