Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Kayongo, Alex; Nyiro, Brian; Siddharthan, Trishul; Kirenga, Bruce; Joloba, Moses; Ellner, Jerrold J.; Salgame, Padmini

doi:10.3389/fcimb.2023.1146571

Cited by 5 publications

(1 citation statement)

References 293 publications

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“…The interaction of host response, along with the respiratory epithelial cells, extracellular matrix and fibroblasts will culminate in continuous chronic lung inflammation, causing the necrosis of tissues also airway remodeling, as the result, there would be structural changes and these changes gradually compromise lung function. 13 A pneumothorax is a condition in which an air from outside of the lung is trapped within the pleural cavity. This could leads to many problems related with ventila- in a patient with pre-existing lung disease, patient in this case has a history of lung tuberculosis, therefore his pneumothorax can be classified as SSP.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Pneumothorax in a Patient with Post-Tuberculosis Sequelae: A Case Report

Brama,

Putra

2024

MRJ

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Introduction: Tuberculosis and its complications could lead to a condition with a high mortality and morbidity in which those complications include hemoptysis, pleural effusions, post tubercular lung disease and spontaneous pneumothorax. Pneumothorax in one possible complication in pulmonary tuberculosis with an incidence rate up to 1.5%. Case: A 46 years old man came to emergency room due to shortness of breath that had been felt since one week before and worsened after lifting some weight things 30 minutes prior the admission, the shortness of breath was described as heavy sensation whenever patient breaths, this complaint was accompanied by pain in the right lung, he has a history of lung tuberculosis and had completed his treatment, radiology examination showed right pneumothorax and later patient was hospitalized for a week with Water Seal Drainage (WSD) placed in his right lung. One month later, patient came back to emergency room with the same symptoms and was hospitalized again, but this time, pleurodesis was done. Discussion: Tuberculosis causes damage to lung structure, and disturb its function leaving a sequelae and causing disability called post-tuberculosis lung disease (PTLD). Secondary spontaneous pneumothorax is pneumothorax that occurring in a setting of underlying lung disease. Patients with SSP tolerate pneumothorax less well and display heavier symptoms, even if the pneumothorax is relatively small in size. Conclusions: The inflammation and fibrosis process on Tuberculosis infection leaves a sequelae damage and increased the vulnerability of someone lung’s that could lead to many complications such as pneumothorax. Key words: Pneumothorax, Post-Tuberculosis Sequelae, Recurrent.

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Section: Discussionmentioning

confidence: 99%

Recurrent Pneumothorax in a Patient with Post-Tuberculosis Sequelae: A Case Report

Brama,

Putra

2024

MRJ

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Isoniazid Hybrids As Potential Antitubercular Agents

Mishra,

Kumar,

Singh

2024

ChemistrySelect

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The rapid emergence of various forms of drug‐resistant tuberculosis (TB) has massively impacted people's health globally. According to the WHO, TB care and facilities have been downgraded by 21% since the COVID‐19 pandemic, which has further slowed down the progress toward the “End TB Strategy.” Multiple studies have shown drug‐resistant tuberculosis to be resilient to front‐line antituberculosis drugs, including isoniazid (INH), thus constantly prompting researchers worldwide to probe new potent chemical entities to replace/supplement the current artillery of anti‐TB therapeutics. The molecular hybridization (MH) technique has recently been adopted by many synthetic and medicinal chemists to combine different pharmacophoric units into a single molecular architecture which in most cases has been reported to exhibit a better pharmacological profile as compared to its precursors. The present review provides a concise account of the MH hybridization strategies directed at the structural manipulations of isoniazid to develop new anti‐TB agents and their structure‐activity relationships. Furthermore, their toxicity profiles and docking studies with relevant receptors are also briefly discussed.

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Integrating Artificial Intelligence for Enhanced Tuberculosis Diagnosis and Management: A Comprehensive Analysis

Vyas,

Pratap Singh,

Dave

et al. 2024

Smart Healthcare and Machine Learning

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Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Cited by 5 publications

References 293 publications

Recurrent Pneumothorax in a Patient with Post-Tuberculosis Sequelae: A Case Report

Recurrent Pneumothorax in a Patient with Post-Tuberculosis Sequelae: A Case Report

Isoniazid Hybrids As Potential Antitubercular Agents

Integrating Artificial Intelligence for Enhanced Tuberculosis Diagnosis and Management: A Comprehensive Analysis

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