Mechanisms of mammary cancer chemoprevention by organoselenium compounds

El‐Bayoumy, Karam; Sinha, Raghu

doi:10.1016/j.mrfmmm.2004.02.023

Cited by 171 publications

(98 citation statements)

References 56 publications

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“…In addition to its antioxidant functions, Se is needed for a variety of other functions including neutrophil responses to pathogens [166], cell cycling [167], and metabolism of carcinogens [168].…”

Section: Seleniummentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

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Cross

et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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Section: Seleniummentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

White

Cross

et al. 2007

Free Radical Biology and Medicine

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“…The anticancer activity of selenium is well documented (Ip et al, 2002;El Bayoumy and Sinha, 2004). Selenomethionine is the reagent of choice in a number of human intervention trials with prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells

Bihani

et al. 2005

Oncogene

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“…To date, the use of the micronutrient, selenium, in human clinical trials is limited, but the outcomes of these investigations indicate that selenium is a most promising agents [8]. The trace element selenium has been implicated in chemoprevention and drug-resistance through the reduction of oxidative stress.…”

mentioning

confidence: 99%

“…Synthetic organoselenium compounds inhibit the initiation phase of carcinogenesis by inhibiting DMBA-DNA adduct formation in the target organ in vivo. cDNA microarray analysis has indicated that selenium compounds alter genes in a manner that leads to inhibition of cell proliferation and induction of apoptosis, and modulation of apoptosis and cell proliferation can account for chemoprevention during the post-initiation phase of mammary carcinogenesis [8].…”

mentioning

confidence: 99%

Inhibition of DMBA Induced Rat Mammary Duct Damage by Novel Synthetic Organoselenium Compounds

et al. 2006

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Mechanisms of mammary cancer chemoprevention by organoselenium compounds

Cited by 171 publications

References 56 publications

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells

Inhibition of DMBA Induced Rat Mammary Duct Damage by Novel Synthetic Organoselenium Compounds

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