Mechanisms of melanogenesis inhibition by tumor necrosis factor‐α in B16/F10 mouse melanoma cells

Martínez‐Esparza, María; Jiménez‐Cervantes, Celia; Solano, Francisco; Lozano, José Antonio; García‐Borrón, José C.

doi:10.1046/j.1432-1327.1998.2550139.x

Cited by 107 publications

(67 citation statements)

References 13 publications

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“…Despite its inhibitory activity, the minimal level of ZAG is also required for melanin synthesis. As previously reported, tumor necrosis factor-a also inhibits melanin synthesis by human primary melanoma and B16 melanoma cells (137,138), but ZAG inhibits melanin synthesis by B16 cells via a tumor necrosis factor -independent mechanism. ZAG is produced by normal epidermal keratinocytes, where its expression increases with cellular differentiation (29).…”

Section: Regulation Of Melanin Productionsupporting

confidence: 77%

Zinc α2-Glycoprotein: A Multidisciplinary Protein

Hassan

Waheed

Yadav

et al. 2008

Molecular Cancer Research

216

204

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Zinc A2-glycoprotein (ZAG) is a protein of interest because of its ability to play many important functions in the human body, including fertilization and lipid mobilization. After the discovery of this molecule, during the last 5 decades, various studies have been documented on its structure and functions, but still, it is considered as a protein with an unknown function. Its expression is regulated by glucocorticoids. Due to its high sequence homology with lipid-mobilizing factor and high expression in cancer cachexia, it is considered as a novel adipokine. On the other hand, structural organization and fold is similar to MHC class I antigen-presenting molecule; hence, ZAG may have a role in the expression of the immune response. The function of ZAG under physiologic and cancerous conditions remains mysterious but is considered as a tumor biomarker for various carcinomas. There are several unrelated functions that are attributed to ZAG, such as RNase activity, regulation of melanin production, hindering tumor proliferation, and transport of nephritic by-products. This article deals with the discussion of the major aspects of ZAG from its gene structure to function and metabolism. (Mol Cancer Res 2008;6(6):892 -906)

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Section: Regulation Of Melanin Productionsupporting

confidence: 77%

Zinc α2-Glycoprotein: A Multidisciplinary Protein

Hassan

Waheed

Yadav

et al. 2008

Molecular Cancer Research

216

204

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“…In vitro direct analyses of skin T cells from the margins of vitiliginous skin have shown that polarized type-1 T cells (CD4+ and CD8+), which secrete predominantly TNF-a and interferon-g, are associated with the destruction of melanocytes during active vitiligo (Huang et al, 2002;Wankowicz-Kalinska et al, 2003). In addition to causing apoptosis of melanocytes, TNF-α also inhibits melanocytogenesis through an inhibitory effect on tyrosinase and tyrosinase-related protein (Martínez-Esparza et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with vitiligo

Al-Harthi

Zouman²,

Arfin³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical role in several autoimmune diseases including vitiligo. The aim of present study was to determine the association of TNF-α and -β gene polymorphisms with vitiligo in Saudi patients. TNF-α and -β genes were amplified in 123 Saudi patients and 200 matched controls using polymerase chain reaction to search for polymorphisms involved at positions -308, and intron 1 +252. The frequency of the TNF-α (-308) GA genotype was higher and the frequencies of the GG and AA genotypes were significantly lower in vitiligo patients compared to controls. These findings suggested that genotype GA-positive individuals at position -308 of TNF-α are susceptible to vitiligo, whereas the GG and AA genotypes might exert a protective effect. The frequency of allele A (TNF-α 2-allele) was significantly higher and that of allele G (TNF-α 1-allele) was lower in vitiligo patients compared to controls, indicating an association of allele A with susceptibility to TNF-α and -β polymorphisms in vitiligo vitiligo in Saudi patients. The results of our examination of TNF-β (intron 1 +252) polymorphisms showed a significant increase in the frequency of the GG genotype and allele G (TNF-b 1-allele) in vitiligo patients, suggesting a susceptibility of the GG genotype and allele G for vitiligo. By contrast, the high frequency of the GA genotype in controls might indicate a protective effect. The results of the present study strongly support a link between TNF-α (-308) and -β (intron 1 +252) polymorphisms and vitiligo in Saudi patients.

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“…Measurement of Tyrosinase Activity Tyrosinase activity was measured using the method of Martinez-Esparza et al 20) Cells were pretreated with 1-30 mM of 3 compounds for 72 h. The cells were then washed twice with ice-cold PBS and lysed in lysis buffer (80 mM PO 4 bufferϩ1% Triton X-100ϩ100 mg/ml phenylmethanesulphonylfluoride (PMSF)) for 2 h in a deep freezer. Lysates were centrifuged at 12500 rpm for 15 min to remove insoluble material.…”

Section: Measurement Of Melanin Contentmentioning

confidence: 99%

Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from <i>Kaempferia pandurata</i> R<small>OXB</small>.

Yoon

Shim

Cho

et al. 2007

Biological & Pharmaceutical Bulletin

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Melanin is the phenolic biopolymer that is responsible for pigmentation. Although melanin plays a crucial role in absorbing free radicals from the cytoplasm and shielding from UV light, the overproduction and accumulation of melanin in the skin could be a serious skin disorder. 1) Current therapies for skin pigmentation disease are unsatisfactory. Thus the search for natural and synthetic chemical agents to modulate the metabolism of pigmentation is of great interest. 2)Melanin biosynthesis occurs in a cascade of enzymatic and spontaneous reactions that convert tyrosine to melanin pigments.3) The initial and rate-limiting step in melanin synthesis, the hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA), is controlled by tyrosinase that is the key enzyme in the process. 4) Since the 1980s, skin cancer researchers have studied the melanin biosynthetic pathways, which led to the development of whitening cosmetics and medicines.5) Arbutin, kojic acid, hydroquinone and its derivatives were developed in 1980s.6) However, the clinical effects of those chemicals are unsatisfactory because of their low activity and cell toxicity. 7) Therefore there is a need for safe and effective whitening agents.Kaempferia pandurata ROXB. is a perennial herb of the Zingiberaceae family mainly cultivated in tropical countries, including Indonesia and Thailand. The fresh rhizome has been used as a food ingredient and as a folk medicine for the treatment of colic, dry cough, rheumatism, musle pain, and as an aphrodisiac.8) Several studies reported various activities of K. pandurata, including antiinflammatory, antitumor, antidiarrhea, antidysentery, antiflatulence, and antiepidermophytid effects. 9) Isopanduratin A and 4-hydroxypanduratin A (Fig. 1) are the typical chalcone compounds found in K. pandurata. Chalcones belong to a group of phenolic compounds in the flavonoid family and widely occur in nature as pigments. This category of flavonoids has a broad bioactive spectrum such as anticancer, antibacterial, antifungal activities, etc. [10][11][12] In previous studies, chalcone compounds in K.pandurata showed anticancer, antioxidative, antimutagenic, and antibacterial activities. [13][14][15] However, their depigmenting effect has not yet been examined. Therefore we focused on evaluating the inhibitory effects of chalcone compounds isolated from K. pandurata on melanin biosynthesis and tyrosinase. Seocheon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, South Korea: and c R&D Center, Amore-Pacific Corporation; 314-1, Bora-dong, Kiheung-gu, Yongin-si, Kyounggi-do 449-729, South Korea. Received April 11, 2007; accepted July 20, 2007 This study was carried out to investigate the in vitro effects of isopanduratin A and 4-hydroxypanduratin A isolated from Kaempferia pandurata ROXB. on melanin biosynthesis and tyrosinase activity. Two chalcone compounds, isopanduratin A and 4-hydroxypanduratin A, were isolated from the ethyl acetate fraction of ethanol extract as the active principles. Compared with phenylthiourea (IC 50 ‫3.4...

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Mechanisms of melanogenesis inhibition by tumor necrosis factor‐α in B16/F10 mouse melanoma cells

Cited by 107 publications

References 13 publications

Zinc α2-Glycoprotein: A Multidisciplinary Protein

Zinc α2-Glycoprotein: A Multidisciplinary Protein

Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with vitiligo

Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from <i>Kaempferia pandurata</i> R<small>OXB</small>.

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