Mechanisms of memory impairment in animal models of nontraumatic intracranial hemorrhage: A systematic review of the literature

Peterson, Catherine; Umoye, Alexis O.; Puglisi, Chloe H.; Waldau, Ben

doi:10.1016/j.hest.2021.08.002

Cited by 2 publications

(1 citation statement)

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“…However, post-ICH, white matter injury, and secondary ischemic lesions are also not uncommon [34,[235][236][237]. White matter lesions after brain hemorrhage are often associated with poor outcomes [238][239][240][241]. Neuroinflammation, oxidative stress, and excitotoxicity play a critical role in demyelination, axonal damage, and loss of oligodendrocytes after ICH [34,242,243].…”

Section: Hv1 Demyelination and Myelin Repair In Strokementioning

confidence: 99%

The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair

Tang,

Wu,

et al. 2023

Aging and disease

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In the central nervous system (CNS), the myelin sheath ensures efficient interconnection between neurons and contributes to the regulation of the proper function of neuronal networks. The maintenance of myelin and the well-organized subtle process of myelin plasticity requires cooperation among myelin-forming cells, glial cells, and neural networks. The process of cooperation is fragile, and the balance is highly susceptible to disruption by microenvironment influences. Reactive microglia play a critical and complicated role in the demyelination and remyelination process. Recent studies have shown that the voltage-gated proton channel Hv1 is selectively expressed in microglia in CNS, which regulates intracellular pH and is involved in the production of reactive oxygen species, underlying multifaceted roles in maintaining microglia function. This paper begins by examining the molecular mechanisms of demyelination and emphasizes the crucial role of the microenvironment in demyelination. It focuses specifically on the role of Hv1 in myelin repair and its therapeutic potential in CNS demyelinating diseases.

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