MECHANISMS OF MORPHOLOGY DEATH OF TUMOR CELL BY EFFECT NON-RADIOACTIVE AND RADIOACTIVE 195mPt-CISPLATIN

Abstract

The photonuclear technology of preparation radioactive cisplatin 195mPt was been developed by the bremsstrahlung from the electron accelerators. In the novel technology, the production of 195mPt from reaction 197Au(γ,np)195mPt with a high specific activity >1 Ci/mg-1 was realized. The Ehrlich adenocarcinoma cells were been used as a neoplastic model. There are two groups: 1. tumor cells with non-radioactive cisplatin; 2. tumor cells with radioactive cisplatin (0.17 pg 195mPt-cisplatin). The number of morphology death cells as a result of radioactive cisplatin action was more than after action of non-radioactive cisplatin. The different mechanisms of the morphology death cell (necrosis for non-radioactive and apoptosis for radioactive) were detected.