Mechanisms of natural transmission of Border disease

Barlow, R.M.; Vantsis, J.T.; Gardiner, A.C.; Rennie, James; Herring, J. A.; Scott, Frank

doi:10.1016/0021-9975(80)90028-6

Cited by 23 publications

(5 citation statements)

References 14 publications

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“…These 8 sheep originated from 2 large commercial flocks, which had had no abortions or births of weak lambs in the past few years. It is noteworthy that the virus-positive sheep were clinically healthy, which was in agreement with several reports of healthy persistently-infected lambs (Barlow et al, 1980;Bonniwell et al, 1987;Nettleton et al, 1992). Likewise, a study of Swiss sheep flocks showed that the majority of BDV infections are subclinical or infected lambs only have mild clinical signs that may go unnoticed.…”

Section: Discussionsupporting

confidence: 90%

Infection of cattle with Border disease virus by sheep on communal alpine pastures

Braun

Bachofen

Büchi

et al. 2013

Schweizer Archiv für Tierheilkunde

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The purpose of this study was to investigate whether sheep grazing communal alpine pastures with cattle can transmit Border disease virus (BDV) to cattle. A total of 1170 sheep and 923 cattle were tested for BDV using RT-PCR (sheep) and for pestivirus antibodies using an ELISA (cattle), respectively, before being moved to one of 4 pastures (A, B, C and D). Eight sheep from pasture C were viraemic. 396 of 923 cattle examined before the pasture season were seronegative. The latter were re-examined after the pasture season and 99 were seropositive or indeterminate. Antibody specificity was determined in 25 of these using a serum neutralization test (SNT). BDV infection was confirmed in 10 cattle and was considered likely in 8 others. BVDV infection was confirmed in 4 cattle and considered likely in 3 after pasturing. The study has shown that the transmission of BDV from sheep to cattle is possible on communal alpine pastures.

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Section: Discussionsupporting

confidence: 90%

Infection of cattle with Border disease virus by sheep on communal alpine pastures

Braun

Bachofen

Büchi

et al. 2013

Schweizer Archiv für Tierheilkunde

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“…The pestiviruses are well recognised reproductive pathogens where the outcome of infection is dependent on a number of factors including the pathogenicity of the infecting strain, the stage of gestation that infection occurs in relation to organogenesis and development of immune competence, where infection prior to foetal immunocompetence may result in a persistent infection due to immunotolerance [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Persistently infected (PI) animals remain serologically negative and demonstrate cell-mediated unresponsiveness to the infecting strain, shed virus throughout their lives, and are usually epidemiologically more important in ongoing virus transmission than acute, transiently infected animals [ 5 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. It has been shown experimentally that pigs infected post-natally with Bungowannah virus develop transient infections that resolve over a 10-day period and transmit the virus inefficiently [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Outcome of Porcine Foetal Infection with Bungowannah Virus Is Dependent on the Stage of Gestation at Which Infection Occurs. Part 1: Serology and Virology

Finlaison

Kirkland

2020

Viruses

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Bungowannah virus is a novel porcine pestivirus identified in a disease outbreak in Australia in 2003. The aim of this study was to determine the outcome of infection of the pregnant pig with this virus. Twenty-four pregnant pigs were infected at days 35, 55, 75 or 90 of gestation. Blood, tonsillar and rectal swabs were collected from each pig at birth and then weekly until euthanasia or death. Tissues were sampled at necropsy. Viral load was measured by real-time reverse-transcription polymerase chain reaction (qRT-PCR) and antibody levels in serum by peroxidase-linked immunoassay. Bungowannah virus was detected in the serum and excretions of all infected pigs at birth regardless of the stage of gestation at which infection occurred. Persistent infections occurred following infection prior to the development of foetal immunocompetence. Unexpectedly some animals infected at day 55 of gestation later cleared the virus and seroconverted. Viraemia and viral shedding resolved quickest following infection in late gestation.

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“…These lambs can develop normally and reach mature age. Apart from being potent lateral transmitters of the virus, PI ewes infect their offspring in utero in consecutive years (Barlow et al 1980, Woldehiwet & Nettleton 1991. Postnatal BDV infections are usually subclinical.…”

Section: Bdl; Bvdl'j Interspecies Transmissionmentioning

confidence: 99%

Border Disease Virus Transmitted to Sheep and Cattle by a Persistently Infected Ewe: Epidemiology and Control

Carlsson

Belák

1994

Acta Vet Scand

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Mechanisms of natural transmission of Border disease

Cited by 23 publications

References 14 publications

Infection of cattle with Border disease virus by sheep on communal alpine pastures

Infection of cattle with Border disease virus by sheep on communal alpine pastures

The Outcome of Porcine Foetal Infection with Bungowannah Virus Is Dependent on the Stage of Gestation at Which Infection Occurs. Part 1: Serology and Virology

Border Disease Virus Transmitted to Sheep and Cattle by a Persistently Infected Ewe: Epidemiology and Control

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