Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Modulation of some markers of erectile dysfunction and malonaldehyde levels in isolated rat penile tissue with unripe and ripe plantain peels: identification of the constituents of the plants using HPLC

“…The inhibition of AChE by the extracts substantiate the folkloric use of plantain peels in the management and/or treatment of ED. The inhibition of AChE by the peels correlates with recent studies that plant derived AChE inhibitors can be employed in ameliorating ED, and can also prevent oxidative stress in neuronal cells of penile tissue (Ramassamy 2006;Hostettmann et al 2006;Butterfield and Lauderback 2002;Andersson 2011;Nunes and Webb 2012;Akomolafe et al 2016). The inhibition of AChE by the extracts could be associated with the presence of phenolic compounds.…”

“…But, the increase activity of AChE reduces the concentration of ACh by catalyzing the conversion of acetylcholine to acetate and choline, respectively (Akomolafe et al 2016). As reported, inhibition of AChE increases the level of ACh, and consequently improves penile erection and rigidity (Andersson 2011;Nunes and Webb 2012).…”

Basaal wetenschappelijk bewijs voor de link tussen erectiele disfunctie en cardiometabole disfunctie

“…De peniele erectie komt tot stand door een spinale reflex met stimuli van perifere zenuwen en vanuit het centraal zenuwstelsel [22]. De autonome zenuwvezels (sympathische en parasympathische) in de caverneuze zenuwplexus zijn verantwoordelijk voor de balans tussen contractie en relaxatie van de gladde spieren van de corpora cavernosa; hiermee wordt de instroom van bloed in de corpora cavernosa geregeld, met erectie en detumescentie tot gevolg.…”

Screening of new compounds for the management of erectile dysfunction

“…Penile erection is the end result of relaxation of penile smooth muscles and arterioles, therefore, inability of penile smooth muscles to relax in the presence of sexual stimuli may lead to ED. 1,2 Penis contains three smooth muscle structures i.e., one corpus spongiosum that surrounds urethra and two corpora cavernosa (singular-corpus cavernosum) whose relaxation is responsible for penile erection. New compound that relaxes isolated corpus cavernosum smooth muscles (CCSMs) signifi cantly in vitro would be helpful therapeutic candidate in the management of ED.…”

“…Italiano et al, suggested using corpus cavernosum of rat for investigating erectile pharmacology as penile structure of men and rat are similar. 1,3 Quinlan et al showed that rat can be used as a model for the study of penile erection. Major pelvic ganglions (MPGs) lie on either side of the dorsolateral lobes of the prostate and autonomic nerves (from MPGs) those that innervate penis are known as cavernous nerves (CN).…”