Mechanisms of Physical Stabilization of Concentrated Water-In-Oil Emulsions Probed by Pulse Field Gradient Nuclear Magnetic Resonance and Rheology through a Multiscale Approach

Pradilla, Diego; Barrera, Ana María Bermejo; Sætran, May Grete; Sørland, Geir Humborstad; Álvarez, Óscar

doi:10.1021/acs.langmuir.8b01393

Cited by 18 publications

(7 citation statements)

References 64 publications

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“…Among the most common emulsion stabilizers, low molecular weight surfactants have been broadly used for emulsion stabilization [175][176][177]. However, they are highly toxic for cells, limiting their use in systems with biological applications [178,179].…”

Section: Emulsion Stabilizationmentioning

confidence: 99%

Methods for producing microstructured hydrogels for targeted applications in biology

Garcia

Kiick

2019

Acta Biomaterialia

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Hydrogels have been broadly studied for applications in clinically motivated fields such as tissue regeneration, drug delivery, and wound healing, as well as in a wide variety of consumer and industry uses. While the control of mechanical properties and network structures are important in all of these applications, for regenerative medicine applications in particular, matching the chemical, topographical and mechanical properties for the target use/tissue is critical. There have been multiple alternatives developed for fabricating materials with microstructures with goals of controlling the spatial location, phenotypic evolution, and signaling of cells. The commonly employed polymers such as poly(ethylene glycol) (PEG), polypeptides, and polysaccharides (as well as others) can be processed by various methods in order to control material heterogeneity and microscale structures. We review here the more commonly used polymers, chemistries, and methods for generating microstructures in biomaterials, highlighting the range of possible morphologies that can be produced, and the limitations of each method. With a focus in liquidliquid phase separation, methods and chemistries well suited for stabilizing the interface and arresting the phase separation are covered. As the microstructures can affect cell behavior, examples of such effects are reviewed as well.

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Section: Emulsion Stabilizationmentioning

confidence: 99%

Methods for producing microstructured hydrogels for targeted applications in biology

Garcia

Kiick

2019

Acta Biomaterialia

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“…Emulsions are hierarchically structured systems: their macroscopic stability depends on the mesoscopic dimension and the distribution of the dispersed droplets, which are affected by the microscopic structure and composition of the droplet–continuous medium interface, which in turn are determined by the molecular features of the emulsifiers [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids

et al. 2020

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Water-in-oil (W/O) nanoemulsions stabilized by phospholipids (PLs) are increasingly exploited in a wide spectrum of applications, from pharmaceuticals to food and cosmetic formulations. In this work, we report the design and optimization of an innovative emulsion based on a mixture of phosphoethanolamine (PE) and phosphoglycerol (PG) PLs, inspired by the composition of the inner leaflet of a bacterial outer membrane. Using the natural oil squalene as the continuous organic phase, no additional emulsion stabilizer is needed. On the other hand, a small amount of Span 80 is required when dodecane is used. The obtained nanoemulsions are stable for at least two hours, thus allowing the droplet size and distribution to be characterized by Dynamic Light Scattering (DLS) and the lipid layer structure and dynamics to be analyzed by Electron Paramagnetic Resonance (EPR) spectroscopy. The results indicate that squalene shallowly intercalates among the lipid tail termini, being unable to deeply penetrate the adsorbed lipid monolayer. The altered lipid dynamics are proposed to be the reason for the enhanced emulsion stability, this paving the way to future implementations and possible applications.

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“…Not only do they have lower price and involve null maintenance costs but their operation modes are also easy that do not require an NMR expert and special laboratory requirements. Only a few reports used benchtop equipment to localize the components in a microemulsion, 34 determine diffusion coefficients, 35 monitor the oil saturation in a stone plug, 36 and study the emulsification kinetics. 37 Single-sided NMR sensors combine surface radio frequency (RF) coils and open magnets to generate a sensitive slice external to the sensor and inside the sample under investigation.…”

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Species Distribution in Bicontinuous Phase Systems for Enhanced Oil Recovery Probed by Single-Sided NMR

Velasco

Iborra

Giussi³

et al. 2022

Langmuir

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Multiphase aqueous-organic systems where a bicontinuous phase is in equilibrium with an excess organic and aqueous phase find various applications in industry. These systems�also known as Winsor III�are complex not only for the different phases that develop therein but also because they are multicomponent systems. In this work, we explore for the first time the use of a benchtop low-field single-sided NMR to determine the species distribution in Winsor III systems. The proposed methodology provides information at macroscopic and microscopic levels. In particular, we show the use of single-sided NMR to determine the phases' dimensions and the species distribution in a polymer-based bicontinuous system. The phases' dimensions and limits can be resolved with micrometric precision and are indicative of the bicontinuous phase stability. The species distribution is determined by means of spatially resolved NMR relaxation and diffusion experiments. It was observed that the salinity of the aqueous phase also impacts the species distribution in the bicontinuous system. Experiments show that the additive and the polymer are mainly located in the bicontinuous phase. As the salinity of the aqueous phase increases, the amount of organic components in the bicontinuous phase decreases as a consequence of the species distribution in the system. This influences the total amount of recovered organic liquid from the organic phase. The information is obtained in a relatively fast experiment and is relevant to the system's possible applications, such as enhanced oil recovery (EOR). This methodology is not only circumscribed to its application in EOR but can also be applied to the study of any emulsion or microemulsion systems without sample size or geometry constraints.

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Mechanisms of Physical Stabilization of Concentrated Water-In-Oil Emulsions Probed by Pulse Field Gradient Nuclear Magnetic Resonance and Rheology through a Multiscale Approach

Cited by 18 publications

References 64 publications

Methods for producing microstructured hydrogels for targeted applications in biology

Methods for producing microstructured hydrogels for targeted applications in biology

Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids

Species Distribution in Bicontinuous Phase Systems for Enhanced Oil Recovery Probed by Single-Sided NMR

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