2013
DOI: 10.1002/cne.23387
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Mechanisms of Postecdysis‐Associated Programmed Cell Death of Peptidergic Neurons in Drosophila melanogaster

Abstract: Crustacean cardioactive peptide (CCAP)-expressing neurons undergo programmed cell death (PCD) within 24 hours after adult eclosion. A subset of the doomed CCAP neurons in the ventral nerve cord also expressed the neuropeptide bursicon and thus are referred to as bursCCAP neurons. In this study, we undertook comprehensive genetic and transgenic analyses to dissect the PCD mechanisms of bursCCAP neurons. Expression of a versatile caspase inhibitor, p35, blocked PCD of bursCCAP neurons, suggesting caspase-depende… Show more

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Cited by 20 publications
(42 citation statements)
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References 80 publications
(152 reference statements)
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“…In contrast, expression of DmHid is not pronounced in the CNS according to modENCODE data (The modENCODE consortium, 2010), suggesting that DmHid is not a major player for neuronal apoptosis during metamorphosis. This is consistent with our previous studies, which did not find any role for DmHid in the vCrz and burs neuronal PCD in Drosophila CNS (Choi et al, 2006; Lee et al, 2013a, 2013b). …”
Section: Resultssupporting
confidence: 94%
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“…In contrast, expression of DmHid is not pronounced in the CNS according to modENCODE data (The modENCODE consortium, 2010), suggesting that DmHid is not a major player for neuronal apoptosis during metamorphosis. This is consistent with our previous studies, which did not find any role for DmHid in the vCrz and burs neuronal PCD in Drosophila CNS (Choi et al, 2006; Lee et al, 2013a, 2013b). …”
Section: Resultssupporting
confidence: 94%
“…For instance, metamorphosis-associated degeneration of the salivary glands requires reaper and Hid (Jiang et al, 2000), while Hid is necessary for cell death in response to the depletion of the survival signal (Kuroda and White, 1998; Bergmann et al, 2002). On the other hand, we and others have shown that grim is the principal death inducer for developmentally-regulated PCD of larval neurons producing Corazonin, bursicon, and CCAP neuropeptides (Draizen et al, 1999; Lee et al, 2013a, 2013b). …”
Section: Introductionmentioning
confidence: 90%
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“…Ecdysone acts on type II neurons by inhibiting the expression of reaper and grim , preventing neurons from undergoing PCD. At the same time, CCAP-expressing neurons die in an identical ecdysone decline-dependent manner (Draizen, Ewer et al 1999, Lee, Kikuno et al 2013). …”
Section: Apoptosis In Neuronsmentioning
confidence: 99%
“…reaper and grim are needed to trigger apoptosis of neuroblasts in the abdominal neuromeres (Tan, Yamada-Mabuchi et al 2011). grim appears to regulate apoptosis of neuropeptide-expressing neurons, such as the vCrz (in collaboration with reaper ) (Choi, Lee et al 2006, Lee, Sehgal et al 2013), Capability-expressing Va neurons (Suska, Miguel-Aliaga et al 2011), and CCAP-expressing neurons (Lee, Kikuno et al 2013). It is also important to highlight that even if one of the RHG genes is not expressed in an apoptotic cell, it is often sufficient to trigger apoptosis if mis-expressed in this cell; e.g .…”
Section: Emerging Ideasmentioning
confidence: 99%