1995
DOI: 10.1007/978-3-642-79517-6_9
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms of Renal Damage in Chronic Pyelonephritis (Reflux Nephropathy)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
16
0
3

Year Published

1996
1996
2023
2023

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 42 publications
(20 citation statements)
references
References 97 publications
1
16
0
3
Order By: Relevance
“…In fact, asymptomatic siblings of patients with vesicoureteral reflux and UTI,who were also found to have vesicoureteral reflux, had no UTI prior to the 518 initiation of prophylactic antibiotics [27]. While renal damage (reflux nephropathy) can occur from a combination of reflux and infection [28], reflux is not necessary for a kidney infection to occur in either the experimental animal or child [29,30]. Vesicoureteral reflux by itself, in the absence of abnormal high bladder pressures, does not cause renal damage, except in infants with fetal vesicoureteral reflux [31].…”
Section: Host Factorsmentioning
confidence: 98%
“…In fact, asymptomatic siblings of patients with vesicoureteral reflux and UTI,who were also found to have vesicoureteral reflux, had no UTI prior to the 518 initiation of prophylactic antibiotics [27]. While renal damage (reflux nephropathy) can occur from a combination of reflux and infection [28], reflux is not necessary for a kidney infection to occur in either the experimental animal or child [29,30]. Vesicoureteral reflux by itself, in the absence of abnormal high bladder pressures, does not cause renal damage, except in infants with fetal vesicoureteral reflux [31].…”
Section: Host Factorsmentioning
confidence: 98%
“…The scars could be described as Y-shaped, flat, broad-based depressions with redbrown granular bases. Usually, there is a polar scarring with underlying calyceal distortion and blunting with thin parenchyma that the cortico-medullary demarcation is lost [113]. There are microscopic changes that are usually patchy together with an interstitial infiltrate of lymphocytes, plasma cells, and occasional polymorphonuclear cells.…”
Section: Pathologymentioning
confidence: 99%
“…At times, leukocytes and hyaline casts are present in the tubules that the latter may resemble the thyroid colloid where the description renal thyroidization is originated [114]. On the whole, the changes are nonspecific that could be seen in toxic exposures, post-obstructive atrophy, hematologic disorders, post irradiation nephritis, ischemic renal disease, and nephrosclerosis too [113].…”
Section: Pathologymentioning
confidence: 99%
“…aetiology, pathophysiology, prevalence, associations) is important before conthat this induces are followed, on resolution, by interstitial damage and ultimately the development of scar sidering the pathophysiology of hypertension in this condition. Primary VUR is common in young children tissue in the aCected segment of the kidney [34]. Evidence has emerged from animal work indicating the need for (with an estimated incidence in the general population of 0.1-1% [14,15] and in children presenting with UTI infection in addition to reflux for this process to occur, although in an obstructed system scarring can develop of 12-50% [14,16]), but disappears with time in most (80%) [17,18].…”
Section: Introductionmentioning
confidence: 99%