Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway

Gao, Yang; Kang, Kai; Li, Nana; Han, Qiuyuan; Liu, Haitao; Kong, Wei; Zhang, Xing; Huang, Rui; Yang, Zhenyu; Qi, Zhi-Dong; Zheng, Jie; Li, Ming; Wang, Hongliang; Li, Jia-Yu; Liu, Ruijin; Wang, Si-Cong; Zhang, Weihua; Zhao, Mingyan; Yu, Kaijiang

doi:10.1007/s10753-020-01374-y

Cited by 5 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported in another study that α7nAChR in macrophages was activated by acetylcholine released from the vagus nerve subjected to stimulation, while vagus nerve stimulation reduced renal I/R injury [ 31 ]. α7nAChR could be activated by Dexmedetomidine to effectively alleviate Lipopolysaccharide-induced kidney injury in mice [ 32 ]. In our study, the expression of α7nAChR in the kidney of preeclampsia rats, results of which showed that renal α7nAChR expression was downregulated in preeclampsia rats compared with normal animals.…”

Section: Discussionmentioning

confidence: 99%

Ropivacaine with intraspinal administration alleviates preeclampsia-induced kidney injury via glycocalyx /alpha 7 nicotinic acetylcholine receptor pathway

Sun

Tian

et al. 2022

Bioengineered

View full text Add to dashboard Cite

Preeclampsia is characterized by hypertension and proteinuria, which is associated with kidney injury. Glycocalyx (GCX) degradation mediated endothelial injury can result in proteinuria and kidney damage. alpha 7 nicotinic acetylcholine receptor (α7nAChR) connects nervous and immune systems to respond to stress or injury. We aimed to explore the protective effect and mechanism of intraspinal analgesia on maternal kidney injury in preeclampsia. Endotoxin-induced preeclampsia rats treated with ropivacaine via intraspinal administration. Renal histopathological examination was performed, cell apoptosis in the kidney, the levels of Glycocalyx markers of Syndecan-1 and heparin sulfate (HS) in maternal serum, Syndecan-1 along with α7nAChR in the kidney were measured. Our results showed that kidney injury was obviously in preeclampsia rats with proteinuria, endothelial damage, higher apoptosis rate, increasing levels of Syndecan-1 and HS in serum, upregulated Syndecan-1 expression but downregulated α7nAChR expression in kidney. Preeclampsia rats treated with intraspinal injected ropivacaine attenuated preeclampsia-induced kidney injury as Syndecan-1 and HS were decreased in serum, Syndecan-1 expression was suppressed as well as α7nAChR was activated in the kidney. Our results suggested that Ropivacaine administered through the spinal canal may protect preeclampsia-induced renal injury by decreasing GCX and α7nAChR activation.

show abstract

Section: Discussionmentioning

confidence: 99%