Mechanisms of resistance to azacitidine in human leukemia cell lines

Teriflunomide Restores 5-Azacytidine Sensitivity Via Activation of Pyrimidine Salvage in 5-Azacytidine-Resistant Leukemia Cells

“…Evidence suggests that AZA resistance requires a shift in the pyrimidine-supplying pathway from salvagedependent to de novo synthesis-dependent [7,20]. In the current study, we demonstrated that teriflunomide prevented the acquisition of AZA resistance.…”

Lack of cross‐resistance to FF‐10501, an inhibitor of inosine‐5′‐monophosphate dehydrogenase, in azacitidine‐resistant cell lines selected from SKM‐1 and MOLM‐13 leukemia cell lines

“…1982; Sripayap et al. 2014) and overall survival of patients expressing lower levels of UCK1 was shorter than that of patients with median levels of UCK1 (Valencia et al. 2014), and loss of DCK function was also reported in decitabine‐resistant cells (Qin et al.…”

“…2011; Sripayap et al. 2014). SKM‐1 cell line was established from a patient with AML following MDS (Kawaguchi et al.…”

“…Another study has also suggested that UCK2 gene mutation is related to azacitidine resistance (Sripayap et al. 2014). In clinical situations, furthermore, decreased expression of UCK1 was reported in azacitidine‐resistant MDS patients (Valencia et al.…”

Drug resistance-related microRNAs in hematological malignancies: Translating basic evidence into therapeutic strategies

“…Cell apoptosis is a complex process that may be achieved through activation of a cascade of intracellular factors known as caspases [23][24][25]. Therefore, defects in these components involved in this process may cause uncontrolled cell proliferation, a crucial step in the development of MDR [26,27]. An increasing number of studies have highlighted miRNAs as important regulators of cell death that act as either anti-apoptotic or proapoptotic molecules [28,29].…”